产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0216, RRID:AB_2833346.
展开/折叠
Femalysin; Matrix metallopeptidase 21; Matrix metallopeptidase 23A (pseudogene); Matrix metallopeptidase 23A; Matrix metallopeptidase 23B; Matrix metalloproteinase 22; Matrix metalloproteinase 23; Matrix metalloproteinase 23B; Matrix metalloproteinase in the female reproductive tract; Matrix metalloproteinase-21; Matrix metalloproteinase-22; Matrix metalloproteinase-23; MIFR; MIFR-1; MIFR1; MMP 23; MMP-21; MMP-22; MMP-23; MMP21; MMP22; MMP23_HUMAN; MMP23A; MMP23B; soluble form;
抗原和靶标
- O75900 MMP23_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGRGARVPSEAPGAGVERRWLGAALVALCLLPALVLLARLGAPAVPAWSAAQGDVAALGLSAVPPTRVPGPLAPRRRRYTLTPARLRWDHFNLTYRILSFPRNLLSPRETRRALAAAFRMWSDVSPFSFREVAPEQPSDLRIGFYPINHTDCLVSALHHCFDGPTGELAHAFFPPHGGIHFDDSEYWVLGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRGWKALSQDELWGLHRLYGCLDRLFVCASWARRGFCDARRRLMKRLCPSSCDFCYEFPFPTVATTPPPPRTKTRLVPEGRNVTFRCGQKILHKKGKVYWYKDQEPLEFSYPGYLALGEAHLSIIANAVNEGTYTCVVRRQQRVLTTYSWRVRVRG
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O75900 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y79 | Phosphorylation | Uniprot | |
| Y95 | Phosphorylation | Uniprot | |
| S138 | Phosphorylation | Uniprot | |
| K328 | Acetylation | Uniprot | |
| K336 | Acetylation | Uniprot |
研究背景
Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).
N-glycosylated.
Proteolytic cleavage might yield an active form.
Endoplasmic reticulum membrane>Single-pass type II membrane protein. Membrane>Single-pass type II membrane protein.
Note: A secreted form produced by proteolytic cleavage may also exist.
Predominantly expressed in ovary, testis and prostate.
The ShKT domain associates with, and blocks several potassium channels in the nanomolar to low micromolar range. The relative affinity is Kv1.6 > Kv1.3 > Kv1.1 = Kv3.2 > Kv1.4 (By similarity).
Belongs to the peptidase M10A family.
限制条款
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