| 产品: | TACC1 抗体 |
| 货号: | AF0456 |
| 描述: | Rabbit polyclonal antibody to TACC1 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 87kDa; 88kD(Calculated). |
| 蛋白号: | O75410 |
| RRID: | AB_2834182 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0456, RRID:AB_2834182.
展开/折叠
DKFZp686K18126; Ga 55; Ga55; Gastric cancer antigen Ga 55; Gastric cancer antigen Ga55; KIAA1103; TACC 1; Tacc1; TACC1_HUMAN; Taxin 1; Taxin-1; Taxin1; Transforming acidic coiled coil containing protein 1; Transforming acidic coiled-coil-containing protein 1;
抗原和靶标
Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.
- O75410 TACC1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAFSPWQILSPVQWAKWTWSAVRGGAAGEDEAGGPEGDPEEEDSQAETKSLSFSSDSEGNFETPEAETPIRSPFKESCDPSLGLAGPGAKSQESQEADEQLVAEVVEKCSSKTCSKPSENEVPQQAIDSHSVKNFREEPEHDFSKISIVRPFSIETKDSTDISAVLGTKAAHGCVTAVSGKALPSSPPDALQDEAMTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVEGTPLPKASYHFSPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDSGVELGEESRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKLGKTD
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O75410 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S4 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| T48 | Phosphorylation | Uniprot | |
| S50 | Phosphorylation | Uniprot | |
| S52 | Phosphorylation | Uniprot | |
| S54 | Phosphorylation | Uniprot | |
| S55 | Phosphorylation | Uniprot | |
| S57 | Phosphorylation | Uniprot | |
| T63 | Phosphorylation | Uniprot | |
| T68 | Phosphorylation | Uniprot | |
| K75 | Methylation | Uniprot | |
| K75 | Ubiquitination | Uniprot | |
| S94 | Phosphorylation | Uniprot | |
| S131 | Phosphorylation | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| S153 | Phosphorylation | Uniprot | |
| T168 | Phosphorylation | Uniprot | |
| K169 | Ubiquitination | Uniprot | |
| S179 | Phosphorylation | Uniprot | |
| S218 | Phosphorylation | Uniprot | |
| S225 | Phosphorylation | Uniprot | |
| S228 | Phosphorylation | Q9UQB9 (AURKC) | Uniprot |
| K234 | Acetylation | Uniprot | |
| K240 | Acetylation | Uniprot | |
| S248 | Phosphorylation | Uniprot | |
| T257 | Phosphorylation | Uniprot | |
| Y264 | Phosphorylation | Uniprot | |
| S267 | Phosphorylation | Uniprot | |
| T275 | Phosphorylation | Uniprot | |
| S276 | Phosphorylation | Uniprot | |
| K286 | Ubiquitination | Uniprot | |
| S287 | Phosphorylation | Uniprot | |
| S305 | Phosphorylation | Uniprot | |
| S347 | Phosphorylation | Uniprot | |
| T350 | Phosphorylation | Uniprot | |
| K360 | Ubiquitination | Uniprot | |
| S361 | Phosphorylation | Uniprot | |
| S454 | Phosphorylation | Uniprot | |
| K468 | Ubiquitination | Uniprot | |
| K471 | Ubiquitination | Uniprot | |
| T504 | Phosphorylation | Uniprot | |
| K517 | Ubiquitination | Uniprot | |
| Y533 | Phosphorylation | Uniprot | |
| S591 | Phosphorylation | Uniprot | |
| T616 | Phosphorylation | Uniprot | |
| K617 | Ubiquitination | Uniprot | |
| K640 | Acetylation | Uniprot | |
| K640 | Ubiquitination | Uniprot | |
| K647 | Acetylation | Uniprot | |
| K647 | Ubiquitination | Uniprot | |
| K665 | Ubiquitination | Uniprot | |
| S666 | Phosphorylation | Uniprot | |
| S687 | Phosphorylation | Uniprot | |
| K714 | Ubiquitination | Uniprot | |
| Y730 | Phosphorylation | Uniprot | |
| K734 | Ubiquitination | Uniprot | |
| K754 | Acetylation | Uniprot | |
| K756 | Ubiquitination | Uniprot | |
| S759 | Phosphorylation | Uniprot | |
| K783 | Ubiquitination | Uniprot | |
| K792 | Ubiquitination | Uniprot | |
| K800 | Ubiquitination | Uniprot |
研究背景
Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways. Might promote the nuclear localization of the receptors. Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.
Isoform 1 is heavily phosphorylated; isoform 6 is not.
Cytoplasm. Nucleus. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Midbody.
Note: Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis.
Membrane>Lipid-anchor.
Cytoplasm.
Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.
Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with AURKA, AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF. Interacts with the thyroid hormone receptors THRB and THRA, predominantly with isoform alpha-2. The interaction with THRA isoform alpha-1 and THRB is decreased in the presence of thyroid hormone T3. Also interacts with other nuclear receptors, including ESR1, NR3C1, PPARG, RARA and RXRA, preferentially in the absence of their hormonal ligands.
Belongs to the TACC family.
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