| 产品: | CDKA2 抗体 |
| 货号: | AF0350 |
| 描述: | Rabbit polyclonal antibody to CDKA2 |
| 应用: | WB IHC |
| 反应: | Human, Mouse |
| 分子量: | 13kDa; 13kD(Calculated). |
| 蛋白号: | O75956 |
| RRID: | AB_2834190 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0350, RRID:AB_2834190.
展开/折叠
CDK2 associated protein 2; CDK2-associated protein 2; CDK2AP2; CDKA2_HUMAN; Cyclin dependent kinase 2 associated protein 2; Cyclin-dependent kinase 2-associated protein 2; DOC 1 related protein; DOC-1-related protein; DOC-1R; DOC1R; FLJ10636; p14; tumor suppressor deleted in oral cancer related 1;
抗原和靶标
A synthesized peptide derived from human CDKA2, corresponding to a region within C-terminal amino acids.
- O75956 CDKA2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSYKPIAPAPSSTPGSSTPGPGTPVPTGSVPSPSGSVPGAGAPFRPLFNDFGPPSMGYVQAMKPPGAQGSQSTYTDLLSVIEEMGKEIRPTYAGSKSAMERLKRGIIHARALVRECLAETERNART
翻译修饰 - O75956 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K96 | Ubiquitination | Uniprot | |
| S97 | Phosphorylation | Uniprot |
研究背景
Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes (By similarity). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A.
Phosphorylated by MAPK1 and CDK2.
Cytoplasm. Nucleus.
Note: Accumulates in immature oocytes in the nucleus. During the first meiotic division, accumulates in the cytoplasm and localizes in dots in the vicinity of the chromosomes in a region enriched in microtubules.
Ubiquitous.
Interacts with CDK2AP1. Interacts with CDK2. Interacts with MAPK1 (By similarity).
Belongs to the CDK2AP family.
限制条款
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