产品: NDUC2 抗体
货号: AF0351
描述: Rabbit polyclonal antibody to NDUC2
应用: WB IHC
反应: Human, Rat
分子量: 14kDa; 14kD(Calculated).
蛋白号: O95298
RRID: AB_2834196

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
IHC 1:50-1:200, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Rat
克隆:
Polyclonal
特异性:
NDUC2 Antibody detects endogenous levels of total NDUC2.
RRID:
AB_2834196
引用格式: Affinity Biosciences Cat# AF0351, RRID:AB_2834196.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

B14.5b; CI-B14.5b; Complex I B14.5b; Complex I subunit B14.5b; Complex I-B14.5b; HLC-1; HLC1; Human lung cancer oncogene 1 protein; NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa; NADH dehydrogenase [ubiquinone] 1 subunit C2; NADH dehydrogenase ubiquinone 1 subunit C2; NADH ubiquinone oxidoreductase subunit B14.5b; NADH-ubiquinone oxidoreductase subunit B14.5b; NADHDH2; NDUC2_HUMAN; NDUFC2;

抗原和靶标

免疫原:

A synthesized peptide derived from human NDUC2, corresponding to a region within C-terminal amino acids.

Uniprot:
基因/基因ID:
描述:
NDUFC2 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I NDUFC2 subunit family. Complex I is composed of 45 different subunits.
序列:
MIARRNPEPLRFLPDEARSLPPPKLTDPRLLYIGFLGYCSGLIDNLIRRRPIATAGLHRQLLYITAFFFAGYYLVKREDYLYAVRDREMFGYMKLHPEDFPEEDKKTYGEIFEKFHPIR

翻译修饰 - O95298 作为底物

Site PTM Type Enzyme
S19 Phosphorylation
T54 Phosphorylation
Y80 Phosphorylation
K94 Ubiquitination
K105 Ubiquitination
K106 Ubiquitination
K114 Acetylation
K114 Sumoylation
K114 Ubiquitination

研究背景

功能:

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

细胞定位:

Mitochondrion inner membrane>Single-pass membrane protein>Matrix side.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Complex I is composed of 45 different subunits.

蛋白家族:

Belongs to the complex I NDUFC2 subunit family.

研究领域

· Human Diseases > Endocrine and metabolic diseases > Non-alcoholic fatty liver disease (NAFLD).

· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.

· Human Diseases > Neurodegenerative diseases > Parkinson's disease.

· Human Diseases > Neurodegenerative diseases > Huntington's disease.

· Metabolism > Energy metabolism > Oxidative phosphorylation.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Nervous system > Retrograde endocannabinoid signaling.   (View pathway)

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