| 产品: | PSMD2 抗体 |
| 货号: | AF0707 |
| 描述: | Rabbit polyclonal antibody to PSMD2 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 100kDa; 100kD(Calculated). |
| 蛋白号: | Q13200 |
| RRID: | AB_2834249 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF0707, RRID:AB_2834249.
展开/折叠
26S proteasome non-ATPase regulatory subunit 2; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; 55.11 protein; MGC14274; P97; Proteasome (prosome macropain) 26S subunit non ATPase 2; Proteasome 26S subunit, non-ATPase, 2; Proteasome 26S, subunit 2; Protein 55.11; Psmd2; PSMD2_HUMAN; Rpn1; S2; TNFR associated protein 2; TRAP2; Tumor necrosis factor receptor associated protein 2; Tumor necrosis factor type 1 receptor-associated protein 2;
抗原和靶标
Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.
- Q13200 PSMD2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEEGGRDKAPVQPQQSPAAAPGGTDEKPSGKERRDAGDKDKEQELSEEDKQLQDELEMLVERLGEKDTSLYRPALEELRRQIRSSTTSMTSVPKPLKFLRPHYGKLKEIYENMAPGENKRFAADIISVLAMTMSGERECLKYRLVGSQEELASWGHEYVRHLAGEVAKEWQELDDAEKVQREPLLTLVKEIVPYNMAHNAEHEACDLLMEIEQVDMLEKDIDENAYAKVCLYLTSCVNYVPEPENSALLRCALGVFRKFSRFPEALRLALMLNDMELVEDIFTSCKDVVVQKQMAFMLGRHGVFLELSEDVEEYEDLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYKTHLENNRFGGSGSQVDSARMNLASSFVNGFVNAAFGQDKLLTDDGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLTQIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYDL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q13200 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K8 | Ubiquitination | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| T24 | Phosphorylation | Uniprot | |
| K27 | Ubiquitination | Uniprot | |
| S29 | Phosphorylation | Uniprot | |
| K31 | Ubiquitination | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| K41 | Ubiquitination | Uniprot | |
| S46 | Phosphorylation | Uniprot | |
| K50 | Ubiquitination | Uniprot | |
| K66 | Ubiquitination | Uniprot | |
| R79 | Methylation | Uniprot | |
| K94 | Ubiquitination | Uniprot | |
| K97 | Ubiquitination | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| Y110 | Phosphorylation | Uniprot | |
| K119 | Ubiquitination | Uniprot | |
| S134 | Phosphorylation | Uniprot | |
| R137 | Methylation | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| Y158 | Phosphorylation | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| K178 | Ubiquitination | Uniprot | |
| T186 | Phosphorylation | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| Y194 | Phosphorylation | Uniprot | |
| Y226 | Phosphorylation | Uniprot | |
| K228 | Ubiquitination | Uniprot | |
| K286 | Ubiquitination | Uniprot | |
| K292 | Ubiquitination | Uniprot | |
| K343 | Ubiquitination | Uniprot | |
| Y349 | Phosphorylation | Uniprot | |
| K350 | Acetylation | Uniprot | |
| K350 | Ubiquitination | Uniprot | |
| R357 | Methylation | Uniprot | |
| S361 | Phosphorylation | Uniprot | |
| S363 | Phosphorylation | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| Y432 | Phosphorylation | Uniprot | |
| Y434 | Phosphorylation | Uniprot | |
| S435 | Phosphorylation | Uniprot | |
| S436 | Phosphorylation | Uniprot | |
| Y439 | Phosphorylation | Uniprot | |
| K441 | Ubiquitination | Uniprot | |
| S442 | Phosphorylation | Uniprot | |
| T499 | Phosphorylation | Uniprot | |
| S508 | Phosphorylation | Uniprot | |
| K551 | Ubiquitination | Uniprot | |
| Y554 | Phosphorylation | Uniprot | |
| K623 | Ubiquitination | Uniprot | |
| S711 | Phosphorylation | Uniprot | |
| K712 | Ubiquitination | Uniprot | |
| K754 | Ubiquitination | Uniprot | |
| K773 | Ubiquitination | Uniprot | |
| K858 | Ubiquitination | Uniprot | |
| K860 | Ubiquitination | Uniprot | |
| K902 | Ubiquitination | Uniprot | |
| Y906 | Phosphorylation | Uniprot |
研究背景
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.
Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD2. Interacts with RPGRIP1L (By similarity). Interacts with CRY1 in a KDM8-dependent manner (By similarity).
Belongs to the proteasome subunit S2 family.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > Proteasome.
· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.
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