| 产品: | 磷酸化 B-Myb (Thr494) 抗体 |
| 货号: | AF8031 |
| 描述: | Rabbit polyclonal antibody to Phospho-B-Myb (Thr494) |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 79kDa; 79kD(Calculated). |
| 蛋白号: | P10244 |
| RRID: | AB_2840094 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF8031, RRID:AB_2840094.
展开/折叠
B-Myb; BMyB; MGC15600; MYB L2; Myb related protein B; Myb-like protein 2; Myb-related protein B; MybB; MYBB_HUMAN; MYBL 2; Mybl2; v myb avian myeloblastosis viral oncogene homolog like 2; v myb myeloblastosis viral oncogene homolog (avian) like 2; v myb myeloblastosis viral oncogene homolog like 2;
抗原和靶标
- P10244 MYBB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSRRTRCEDLDELHYQDTDSDVPEQRDSKCKVKWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTIKRKVDTGGFLSESKDCKPPVYLLLELEDKDGLQSAQPTEGQGSLLTNWPSVPPTIKEEENSEEELAAATTSKEQEPIGTDLDAVRTPEPLEEFPKREDQEGSPPETSLPYKWVVEAANLLIPAVGSSLSEALDLIESDPDAWCDLSKFDLPEEPSAEDSINNSLVQLQASHQQQVLPPRQPSALVPSVTEYRLDGHTISDLSRSSRGELIPISPSTEVGGSGIGTPPSVLKRQRKRRVALSPVTENSTSLSFLDSCNSLTPKSTPVKTLPFSPSQFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQKHAAFVTPDQKYSMDNTPHTPTPFKNALEKYGPLKPLPQTPHLEEDLKEVLRSEAGIELIIEDDIRPEKQKRKPGLRRSPIKKVRKSLALDIVDEDVKLMMSTLPKSLSLPTTAPSNSSSLTLSGIKEDNSLLNQGFLQAKPEKAAVAQKPRSHFTTPAPMSSAWKTVACGGTRDQLFMQEKARQLLGRLKPSHTSRTLILS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P10244 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y15 | Phosphorylation | Uniprot | |
| T18 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S20 | Phosphorylation | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| K93 | Sumoylation | Uniprot | |
| K104 | Sumoylation | Uniprot | |
| K134 | Sumoylation | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| K151 | Ubiquitination | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| K173 | Ubiquitination | Uniprot | |
| S178 | Phosphorylation | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| K183 | Ubiquitination | Uniprot | |
| K197 | Sumoylation | Uniprot | |
| T234 | Phosphorylation | Uniprot | |
| K236 | Sumoylation | Uniprot | |
| S241 | Phosphorylation | Uniprot | |
| T266 | Phosphorylation | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| T286 | Phosphorylation | Uniprot | |
| S287 | Phosphorylation | Uniprot | |
| S362 | Phosphorylation | Uniprot | |
| S393 | Phosphorylation | Uniprot | |
| T396 | Phosphorylation | Uniprot | |
| T405 | Phosphorylation | Uniprot | |
| K411 | Ubiquitination | Uniprot | |
| S421 | Phosphorylation | Uniprot | |
| T440 | Phosphorylation | Uniprot | |
| S443 | Phosphorylation | Uniprot | |
| T444 | Phosphorylation | P24941 (CDK2) | Uniprot |
| K447 | Ubiquitination | Uniprot | |
| S452 | Phosphorylation | Uniprot | |
| S454 | Phosphorylation | Uniprot | |
| T465 | Phosphorylation | Uniprot | |
| S470 | Phosphorylation | Uniprot | |
| S472 | Phosphorylation | Uniprot | |
| S475 | Phosphorylation | Uniprot | |
| T476 | Phosphorylation | Uniprot | |
| T486 | Phosphorylation | Uniprot | |
| T487 | Phosphorylation | P24941 (CDK2) | Uniprot |
| T494 | Phosphorylation | P24941 (CDK2) | Uniprot |
| K499 | Ubiquitination | Uniprot | |
| T505 | Phosphorylation | Uniprot | |
| K509 | Sumoylation | Uniprot | |
| K509 | Ubiquitination | Uniprot | |
| T515 | Phosphorylation | Uniprot | |
| T518 | Phosphorylation | Uniprot | |
| T520 | Phosphorylation | P24941 (CDK2) | Uniprot |
| K523 | Ubiquitination | Uniprot | |
| K528 | Ubiquitination | Uniprot | |
| K533 | Acetylation | Uniprot | |
| K533 | Ubiquitination | Uniprot | |
| T538 | Phosphorylation | Uniprot | |
| K546 | Sumoylation | Uniprot | |
| K546 | Ubiquitination | Uniprot | |
| S577 | Phosphorylation | P24941 (CDK2) | Uniprot |
| K584 | Ubiquitination | Uniprot | |
| S585 | Phosphorylation | Uniprot | |
| K596 | Sumoylation | Uniprot | |
| K625 | Ubiquitination | Uniprot | |
| S629 | Phosphorylation | Uniprot | |
| K639 | Sumoylation | Uniprot | |
| K639 | Ubiquitination | Uniprot | |
| K648 | Ubiquitination | Uniprot | |
| T693 | Phosphorylation | Uniprot | |
| R695 | Methylation | Uniprot |
研究背景
Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.
Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.
Nucleus.
Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22.
研究领域
· Cellular Processes > Cell growth and death > Cellular senescence. (View pathway)
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
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