| 产品: | 磷酸化 IGF2R (Ser2484) 抗体 |
| 货号: | AF8068 |
| 描述: | Rabbit polyclonal antibody to Phospho-IGF2R (Ser2484) |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Chicken, Xenopus |
| 分子量: | 274kDa; 274kD(Calculated). |
| 蛋白号: | P11717 |
| RRID: | AB_2840131 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF8068, RRID:AB_2840131.
展开/折叠
300 kDa mannose 6 phosphate receptor; 300 kDa mannose 6-phosphate receptor; Cation independent mannose 6 phosphate receptor; Cation-independent mannose-6-phosphate receptor; CD222; CD222 antigen; CI Man 6 P receptor; CI Man-6-P receptor; CI MPR; CI-M6PR; CI-MPR; CIMPR; IGF 2 receptor; IGF 2R; IGF II receptor; IGF-II receptor; IGF2 receptor; Igf2r; Insulin like growth factor 2 receptor; Insulin like growth factor II receptor; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; M6P R; M6P/IGF2 receptor; M6P/IGF2R; M6PR; mannose 6 phosphate receptor; mannose 6 phosphate receptor, cation independent; MPR 300; MPR300; MPRI; MPRI_HUMAN;
抗原和靶标
- P11717 MPRI_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKNNVLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVGDSVLRSATRSLLEFNTTVSCDQQGTNHRVQSSIAFLCGKTLGTPEFVTATECVHYFEWRTTAACKKDIFKANKEVPCYVFDEELRKHDLNPLIKLSGAYLVDDSDPDTSLFINVCRDIDTLRDPGSQLRACPPGTAACLVRGHQAFDVGQPRDGLKLVRKDRLVLSYVREEAGKLDFCDGHSPAVTITFVCPSERREGTIPKLTAKSNCRYEIEWITEYACHRDYLESKTCSLSGEQQDVSIDLTPLAQSGGSSYISDGKEYLFYLNVCGETEIQFCNKKQAAVCQVKKSDTSQVKAAGRYHNQTLRYSDGDLTLIYFGGDECSSGFQRMSVINFECNKTAGNDGKGTPVFTGEVDCTYFFTWDTEYACVKEKEDLLCGATDGKKRYDLSALVRHAEPEQNWEAVDGSQTETEKKHFFINICHRVLQEGKARGCPEDAAVCAVDKNGSKNLGKFISSPMKEKGNIQLSYSDGDDCGHGKKIKTNITLVCKPGDLESAPVLRTSGEGGCFYEFEWHTAAACVLSKTEGENCTVFDSQAGFSFDLSPLTKKNGAYKVETKKYDFYINVCGPVSVSPCQPDSGACQVAKSDEKTWNLGLSNAKLSYYDGMIQLNYRGGTPYNNERHTPRATLITFLCDRDAGVGFPEYQEEDNSTYNFRWYTSYACPEEPLECVVTDPSTLEQYDLSSLAKSEGGLGGNWYAMDNSGEHVTWRKYYINVCRPLNPVPGCNRYASACQMKYEKDQGSFTEVVSISNLGMAKTGPVVEDSGSLLLEYVNGSACTTSDGRQTTYTTRIHLVCSRGRLNSHPIFSLNWECVVSFLWNTEAACPIQTTTDTDQACSIRDPNSGFVFNLNPLNSSQGYNVSGIGKIFMFNVCGTMPVCGTILGKPASGCEAETQTEELKNWKPARPVGIEKSLQLSTEGFITLTYKGPLSAKGTADAFIVRFVCNDDVYSGPLKFLHQDIDSGQGIRNTYFEFETALACVPSPVDCQVTDLAGNEYDLTGLSTVRKPWTAVDTSVDGRKRTFYLSVCNPLPYIPGCQGSAVGSCLVSEGNSWNLGVVQMSPQAAANGSLSIMYVNGDKCGNQRFSTRITFECAQISGSPAFQLQDGCEYVFIWRTVEACPVVRVEGDNCEVKDPRHGNLYDLKPLGLNDTIVSAGEYTYYFRVCGKLSSDVCPTSDKSKVVSSCQEKREPQGFHKVAGLLTQKLTYENGLLKMNFTGGDTCHKVYQRSTAIFFYCDRGTQRPVFLKETSDCSYLFEWRTQYACPPFDLTECSFKDGAGNSFDLSSLSRYSDNWEAITGTGDPEHYLINVCKSLAPQAGTEPCPPEAAACLLGGSKPVNLGRVRDGPQWRDGIIVLKYVDGDLCPDGIRKKSTTIRFTCSESQVNSRPMFISAVEDCEYTFAWPTATACPMKSNEHDDCQVTNPSTGHLFDLSSLSGRAGFTAAYSEKGLVYMSICGENENCPPGVGACFGQTRISVGKANKRLRYVDQVLQLVYKDGSPCPSKSGLSYKSVISFVCRPEARPTNRPMLISLDKQTCTLFFSWHTPLACEQATECSVRNGSSIVDLSPLIHRTGGYEAYDESEDDASDTNPDFYINICQPLNPMHGVPCPAGAAVCKVPIDGPPIDIGRVAGPPILNPIANEIYLNFESSTPCLADKHFNYTSLIAFHCKRGVSMGTPKLLRTSECDFVFEWETPVVCPDEVRMDGCTLTDEQLLYSFNLSSLSTSTFKVTRDSRTYSVGVCTFAVGPEQGGCKDGGVCLLSGTKGASFGRLQSMKLDYRHQDEAVVLSYVNGDRCPPETDDGVPCVFPFIFNGKSYEECIIESRAKLWCSTTADYDRDHEWGFCRHSNSYRTSSIIFKCDEDEDIGRPQVFSEVRGCDVTFEWKTKVVCPPKKLECKFVQKHKTYDLRLLSSLTGSWSLVHNGVSYYINLCQKIYKGPLGCSERASICRRTTTGDVQVLGLVHTQKLGVIGDKVVVTYSKGYPCGGNKTASSVIELTCTKTVGRPAFKRFDIDSCTYYFSWDSRAACAVKPQEVQMVNGTITNPINGKSFSLGDIYFKLFRASGDMRTNGDNYLYEIQLSSITSSRNPACSGANICQVKPNDQHFSRKVGTSDKTKYYLQDGDLDVVFASSSKCGKDKTKSVSSTIFFHCDPLVEDGIPEFSHETADCQYLFSWYTSAVCPLGVGFDSENPGDDGQMHKGLSERSQAVGAVLSLLLVALTCCLLALLLYKKERRETVISKLTTCCRRSSNVSYKYSKVNKEEETDENETEWLMEEIQLPPPRQGKEGQENGHITTKSVKALSSLHGDDQDSEDEVLTIPEVKVHSGRGAGAESSHPVRNAQSNALQEREDDRVGLVRGEKARKGKSSSAQQKTVSSTKLVSFHDDSDEDLLHI
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P11717 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R7 | Methylation | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| N112 | N-Glycosylation | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| K183 | Ubiquitination | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| T296 | Phosphorylation | Uniprot | |
| T301 | Phosphorylation | Uniprot | |
| T507 | Phosphorylation | Uniprot | |
| N581 | N-Glycosylation | Uniprot | |
| N626 | N-Glycosylation | Uniprot | |
| K687 | Ubiquitination | Uniprot | |
| Y700 | Phosphorylation | Uniprot | |
| Y701 | Phosphorylation | Uniprot | |
| Y709 | Phosphorylation | Uniprot | |
| R710 | Methylation | Uniprot | |
| N747 | N-Glycosylation | Uniprot | |
| K808 | Ubiquitination | Uniprot | |
| K833 | Ubiquitination | Uniprot | |
| K1052 | Ubiquitination | Uniprot | |
| K1104 | Ubiquitination | Uniprot | |
| T1107 | Phosphorylation | Uniprot | |
| T1111 | Phosphorylation | Uniprot | |
| K1230 | Ubiquitination | Uniprot | |
| N1246 | N-Glycosylation | Uniprot | |
| K1264 | Ubiquitination | Uniprot | |
| T1272 | Phosphorylation | Uniprot | |
| K1277 | Sumoylation | Uniprot | |
| S1280 | Phosphorylation | Uniprot | |
| S1281 | Phosphorylation | Uniprot | |
| K1293 | Ubiquitination | Uniprot | |
| K1301 | Ubiquitination | Uniprot | |
| T1346 | Phosphorylation | Uniprot | |
| S1347 | Phosphorylation | Uniprot | |
| Y1592 | Phosphorylation | Uniprot | |
| K1601 | Ubiquitination | Uniprot | |
| S1771 | Phosphorylation | Uniprot | |
| T1774 | Phosphorylation | Uniprot | |
| K1776 | Ubiquitination | Uniprot | |
| T1828 | Phosphorylation | Uniprot | |
| S1831 | Phosphorylation | Uniprot | |
| K1862 | Ubiquitination | Uniprot | |
| S1865 | Phosphorylation | Uniprot | |
| S1871 | Phosphorylation | Uniprot | |
| K1873 | Ubiquitination | Uniprot | |
| T2002 | Phosphorylation | Uniprot | |
| Y2024 | Phosphorylation | Uniprot | |
| Y2025 | Phosphorylation | Uniprot | |
| T2087 | Phosphorylation | Uniprot | |
| Y2154 | Phosphorylation | Uniprot | |
| S2189 | Phosphorylation | Uniprot | |
| T2209 | Phosphorylation | Uniprot | |
| S2210 | Phosphorylation | Uniprot | |
| K2338 | Ubiquitination | Uniprot | |
| S2346 | Phosphorylation | Uniprot | |
| S2347 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S2350 | Phosphorylation | Uniprot | |
| Y2351 | Phosphorylation | Uniprot | |
| K2352 | Acetylation | Uniprot | |
| K2352 | Ubiquitination | Uniprot | |
| Y2353 | Phosphorylation | Uniprot | |
| S2354 | Phosphorylation | Uniprot | |
| T2362 | Phosphorylation | Uniprot | |
| K2383 | Ubiquitination | Uniprot | |
| K2394 | Ubiquitination | Uniprot | |
| S2395 | Phosphorylation | Uniprot | |
| S2400 | Phosphorylation | Uniprot | |
| S2401 | Phosphorylation | Uniprot | |
| S2409 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| T2415 | Phosphorylation | Uniprot | |
| K2420 | Ubiquitination | Uniprot | |
| R2425 | Methylation | Uniprot | |
| K2470 | Ubiquitination | Uniprot | |
| K2476 | Ubiquitination | Uniprot | |
| S2479 | Phosphorylation | Uniprot | |
| S2484 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
研究背景
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
Lysosome membrane>Single-pass type I membrane protein.
Note: Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
Binds HA-I and HA-II plasma membrane adapters (By similarity). Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3.
Contains 15 repeating units of approximately 147 AA harboring four disulfide bonds each. The most highly conserved region within the repeat consists of a stretch of 13 AA that contains cysteines at both ends.
Belongs to the MRL1/IGF2R family.
研究领域
· Cellular Processes > Transport and catabolism > Lysosome. (View pathway)
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
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