| 产品: | 磷酸化 CGK2 (Ser126) 抗体 |
| 货号: | AF8184 |
| 描述: | Rabbit polyclonal antibody to Phospho-CGK2 (Ser126) |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 87 KD; 87kD(Calculated). |
| 蛋白号: | Q13237 |
| RRID: | AB_2840246 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF8184, RRID:AB_2840246.
展开/折叠
CGK 2; cGK2; cGKII; cGMP dependent protein kinase 2; cGMP-dependent protein kinase 2; cGMP-dependent protein kinase II; KGP2_HUMAN; PRKG 2; PRKG2; PRKGR2; Protein kinase, cGMP dependent, type II; Type II cGMP dependent protein kinase;
抗原和靶标
- Q13237 KGP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q13237 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| G2 | Myristoylation | Uniprot | |
| S11 | Phosphorylation | Uniprot | |
| S97 | Phosphorylation | Q13237 (PRKG2) | Uniprot |
| T109 | Phosphorylation | Uniprot | |
| S110 | Phosphorylation | Q13237 (PRKG2) | Uniprot |
| S114 | Phosphorylation | Q13237 (PRKG2) | Uniprot |
| S117 | Phosphorylation | Q13237 (PRKG2) | Uniprot |
| S126 | Phosphorylation | Q13237 (PRKG2) | Uniprot |
| T131 | Phosphorylation | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| K165 | Sumoylation | Uniprot | |
| K165 | Ubiquitination | Uniprot | |
| Y306 | Phosphorylation | Uniprot | |
| Y307 | Phosphorylation | Uniprot | |
| S431 | Phosphorylation | Uniprot | |
| S445 | Phosphorylation | Q13237 (PRKG2) | Uniprot |
| S448 | Phosphorylation | Uniprot | |
| K521 | Methylation | Uniprot |
翻译修饰 - Q13237 作为激酶
| Substrate | Site | Source |
|---|---|---|
| P04626 (ERBB2) | T686 | Uniprot |
| P04792 (HSPB1) | S78 | Uniprot |
| P04792 (HSPB1) | S82 | Uniprot |
| P04792 (HSPB1) | T143 | Uniprot |
| P29474 (NOS3) | T495 | Uniprot |
| P29474 (NOS3) | S633 | Uniprot |
| P29474 (NOS3) | S1177 | Uniprot |
| P30307 (CDC25C) | S216 | Uniprot |
| P32929 (CTH) | S377 | Uniprot |
| P42261 (GRIA1) | S863 | Uniprot |
| P48436 (SOX9) | S181 | Uniprot |
| P49675 (STAR) | S56 | Uniprot |
| P49675 (STAR) | S57 | Uniprot |
| P49675 (STAR) | S100 | Uniprot |
| P49841 (GSK3B) | S9 | Uniprot |
| P50552 (VASP) | S239 | Uniprot |
| P53350 (PLK1) | S137 | Uniprot |
| P55211 (CASP9) | S196 | Uniprot |
| Q01970-1 (PLCB3) | S26 | Uniprot |
| Q01970-1 (PLCB3) | S1105 | Uniprot |
| Q03393 (PTS) | S19 | Uniprot |
| Q12778 (FOXO1) | S319 | Uniprot |
| Q13237 (PRKG2) | S97 | Uniprot |
| Q13237 (PRKG2) | S110 | Uniprot |
| Q13237 (PRKG2) | S114 | Uniprot |
| Q13237 (PRKG2) | S117 | Uniprot |
| Q13237 (PRKG2) | S126 | Uniprot |
| Q13237 (PRKG2) | S445 | Uniprot |
| Q14847-1 (LASP1) | S61 | Uniprot |
| Q14847 (LASP1) | S146 | Uniprot |
| Q15418 (RPS6KA1) | S380 | Uniprot |
| Q9UL51 (HCN2) | S668 | Uniprot |
研究背景
Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity).
Myristoylation mediates membrane localization.
Apical cell membrane>Lipid-anchor.
Highly concentrated in brain, lung and intestinal mucosa.
Interacts with GRIA1/GLUR1.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Gap junction. (View pathway)
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Organismal Systems > Immune system > Platelet activation. (View pathway)
· Organismal Systems > Environmental adaptation > Circadian entrainment.
· Organismal Systems > Nervous system > Long-term depression.
· Organismal Systems > Sensory system > Olfactory transduction.
· Organismal Systems > Endocrine system > Regulation of lipolysis in adipocytes.
· Organismal Systems > Endocrine system > Renin secretion.
· Organismal Systems > Digestive system > Salivary secretion.
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