| 产品: | 磷酸化 CDX2 (Ser283) 抗体 |
| 货号: | AF8253 |
| 描述: | Rabbit polyclonal antibody to Phospho-CDX2 (Ser283) |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Sheep, Rabbit, Chicken |
| 分子量: | 40kd; 34kD(Calculated). |
| 蛋白号: | Q99626 |
| RRID: | AB_2840315 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF8253, RRID:AB_2840315.
展开/折叠
Caudal type homeo box 2; Caudal type homeo box transcription factor 2; Caudal type homeobox 2; Caudal type homeobox protein 2; Caudal type homeobox transcription factor 2; Caudal-type homeobox protein 2; CDX 2; CDX 3; CDX-3; Cdx2; CDX2/AS; CDX2_HUMAN; CDX3; Homeobox protein CDX 2; Homeobox protein CDX-2;
抗原和靶标
- Q99626 CDX2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MYVSYLLDKDVSMYPSSVRHSGGLNLAPQNFVSPPQYPDYGGYHVAAAAAAAANLDSAQSPGPSWPAAYGAPLREDWNGYAPGGAAAAANAVAHGLNGGSPAAAMGYSSPADYHPHHHPHHHPHHPAAAPSCASGLLQTLNPGPPGPAATAAAEQLSPGGQRRNLCEWMRKPAQQSLGSQVKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERKINKKKLQQQQQQQPPQPPPPPPQPPQPQPGPLRSVPEPLSPVSSLQASVPGSVPGVLGPTGGVLNPTVTQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q99626 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S4 | Phosphorylation | Uniprot | |
| S60 | Phosphorylation | Uniprot | |
| S176 | Phosphorylation | Uniprot | |
| S226 | Phosphorylation | Uniprot | |
| S277 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | P24941 (CDK2) , Q16539 (MAPK14) , P49841 (GSK3B) | Uniprot |
| S287 | Phosphorylation | P24941 (CDK2) , Q16539 (MAPK14) | Uniprot |
| S291 | Phosphorylation | P24941 (CDK2) , Q16539 (MAPK14) | Uniprot |
| S295 | Phosphorylation | Q16539 (MAPK14) | Uniprot |
| T310 | Phosphorylation | Uniprot | |
| T312 | Phosphorylation | Uniprot |
研究背景
Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA.
Phosphorylation of Ser-60 mediates the transactivation capacity.
Nucleus.
Belongs to the Caudal homeobox family.
研究领域
· Human Diseases > Cancers: Specific types > Gastric cancer. (View pathway)
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