产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF8262, RRID:AB_2840324.
展开/折叠
CASP; CCAAT displacement protein; CDP; CDP/Cut; CDP1; Clox; COY1; Cut homeobox; Cut homolog; Cut like 1; Cut like homeobox 1; CUTL1; CUX; Cux/CDP; CUX1; Golgi integral membrane protein 6; GOLIM6; Homeobox protein cux 1; Nbla10317; p100; p110; p200; p75; Protein CASP; Putative protein product of Nbla10317;
抗原和靶标
- P39880 CUX1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLCVAGARLKRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVEQAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSENAALRISNSDLSGSARRKGKDQPESRRPGSLPAPPPSQLPRNPGEQASNTNGTHQFSPAGLSQDFFSSSLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSMIFSTGPYSTNSISSQSPLQQSPDVNGMAPSPSQSESAGSVSEGEEMDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQSLNRLFQEVPKRRNGSEGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPAQPSSASGSGNSDDAIRSILQQARREMEAQQAALDPALKQAPLSQSDITILTPKLLSTSPMPTVSSYPPLAISLKKPSAAPEAGASALPNPPALKKEAQDAPGLDPQGAADCAQGVLRQVKNEVGRSGAWKDHWWSAVQPERRNAASSEEAKAEETGGGKEKGSGGSGGGSQPRAERSQLQGPSSSEYWKEWPSAESPYSQSSELSLTGASRSETPQNSPLPSSPIVPMSKPTKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPPIEASKDSKPPEPSDPPASDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGTEYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEDLATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSGRAAPSSEGDSCDGVEATEGPGSADTEEPKSQGEAEREEVPRPAEQTEPPPSGTPGPDDARDDDHEGGPVEGPGPLPSPASATATAAPAAPEDAATSAAAAPGEGPAAPSSAPPPSNSSSSSAPRRPSSLQSLFGLPEAAGARDSRDNPLRKKKAANLNSIIHRLEKAASREEPIEWEF
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P39880 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S59 | Phosphorylation | Uniprot | |
| K83 | Ubiquitination | Uniprot | |
| K117 | Ubiquitination | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| S322 | Phosphorylation | Uniprot | |
| Y351 | Phosphorylation | Uniprot | |
| S363 | Phosphorylation | Uniprot | |
| S369 | Phosphorylation | Uniprot | |
| T374 | Phosphorylation | Uniprot | |
| K388 | Ubiquitination | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| S409 | Phosphorylation | Uniprot | |
| S425 | Phosphorylation | Uniprot | |
| S432 | Phosphorylation | Uniprot | |
| S452 | Phosphorylation | Uniprot | |
| S467 | Phosphorylation | Uniprot | |
| K561 | Ubiquitination | Uniprot | |
| S585 | Phosphorylation | Uniprot | |
| T600 | Phosphorylation | Uniprot | |
| K604 | Acetylation | Uniprot | |
| K611 | Ubiquitination | Uniprot | |
| K647 | Ubiquitination | Uniprot | |
| S652 | Phosphorylation | Uniprot | |
| S663 | Phosphorylation | Uniprot | |
| T665 | Phosphorylation | Uniprot | |
| S667 | Phosphorylation | Uniprot | |
| K672 | Ubiquitination | Uniprot | |
| K679 | Ubiquitination | Uniprot | |
| K686 | Ubiquitination | Uniprot | |
| K729 | Ubiquitination | Uniprot | |
| S734 | Phosphorylation | Uniprot | |
| T739 | Phosphorylation | Uniprot | |
| T742 | Phosphorylation | Uniprot | |
| S755 | Phosphorylation | Uniprot | |
| S756 | Phosphorylation | Uniprot | |
| S763 | Phosphorylation | Uniprot | |
| S768 | Phosphorylation | Uniprot | |
| K811 | Sumoylation | Uniprot | |
| S817 | Phosphorylation | Uniprot | |
| K850 | Acetylation | Uniprot | |
| S868 | Phosphorylation | Uniprot | |
| S874 | Phosphorylation | Uniprot | |
| S887 | Phosphorylation | Uniprot | |
| Y889 | Phosphorylation | Uniprot | |
| S901 | Phosphorylation | Uniprot | |
| S909 | Phosphorylation | Uniprot | |
| S974 | Phosphorylation | Uniprot | |
| K990 | Ubiquitination | Uniprot | |
| S1054 | Phosphorylation | Uniprot | |
| S1059 | Phosphorylation | Uniprot | |
| S1069 | Phosphorylation | Uniprot | |
| T1071 | Phosphorylation | Uniprot | |
| S1100 | Phosphorylation | Uniprot | |
| T1103 | Phosphorylation | Uniprot | |
| T1104 | Phosphorylation | Uniprot | |
| S1115 | Phosphorylation | Uniprot | |
| T1157 | Phosphorylation | Uniprot | |
| S1215 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S1216 | Phosphorylation | Uniprot | |
| S1218 | Phosphorylation | Uniprot | |
| T1230 | Phosphorylation | Uniprot | |
| Y1232 | Phosphorylation | Uniprot | |
| S1233 | Phosphorylation | Uniprot | |
| S1237 | Phosphorylation | P17612 (PRKACA) , P06493 (CDK1) | Uniprot |
| K1256 | Ubiquitination | Uniprot | |
| S1270 | Phosphorylation | P06493 (CDK1) , P17612 (PRKACA) | Uniprot |
| S1312 | Phosphorylation | Uniprot | |
| S1321 | Phosphorylation | Uniprot | |
| S1333 | Phosphorylation | Uniprot | |
| S1337 | Phosphorylation | Uniprot | |
| T1352 | Phosphorylation | Uniprot | |
| S1357 | Phosphorylation | Q13535 (ATR) | Uniprot |
| T1380 | Phosphorylation | Uniprot | |
| S1404 | Phosphorylation | Uniprot | |
| S1454 | Phosphorylation | Uniprot | |
| S1455 | Phosphorylation | Uniprot | |
| S1458 | Phosphorylation | Uniprot | |
| S1486 | Phosphorylation | Uniprot | |
| S1496 | Phosphorylation | Uniprot |
研究背景
Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator.
Nucleus.
Interacts with BANP. Interacts with SATB1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA (By similarity).
Belongs to the CUT homeobox family.
限制条款
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