| 产品: | 磷酸化 RGS19 (Ser151) 抗体 |
| 货号: | AF8274 |
| 描述: | Rabbit polyclonal antibody to Phospho-RGS19 (Ser151) |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 25kDa; 25kD(Calculated). |
| 蛋白号: | P49795 |
| RRID: | AB_2840336 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF8274, RRID:AB_2840336.
展开/折叠
G alpha interacting protein; G protein signalling regulator 19; G protein, alpha-interacting protein; G-alpha-interacting protein; GAIP; GNAI3IP; Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein; Regulator of G protein signalling 19; Regulator of G-protein signaling 19; RGS19; RGS19_HUMAN; RGSGAIP;
抗原和靶标
Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
- P49795 RGS19_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPTPHEAEKQITGPEEADRPPSMSSHDTASPAAPSRNPCCLCWCCCCSCSWNQERRRAWQASRESKLQPLPSCEVCATPSPEEVQSWAQSFDKLMHSPAGRSVFRAFLRTEYSEENMLFWLACEELKAEANQHVVDEKARLIYEDYVSILSPKEVSLDSRVREGINKKMQEPSAHTFDDAQLQIYTLMHRDSYPRFLSSPTYRALLLQGPSQSSSEA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P49795 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S24 | Phosphorylation | P17252 (PRKCA) , P19784 (CSNK2A2) , P68400 (CSNK2A1) | Uniprot |
| S62 | Phosphorylation | Uniprot | |
| S65 | Phosphorylation | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| K138 | Ubiquitination | Uniprot | |
| Y143 | Phosphorylation | Uniprot | |
| Y146 | Phosphorylation | Uniprot | |
| S148 | Phosphorylation | Uniprot | |
| S151 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| K153 | Ubiquitination | Uniprot | |
| T186 | Phosphorylation | Uniprot | |
| S199 | Phosphorylation | Uniprot | |
| T201 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| Y202 | Phosphorylation | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| S213 | Phosphorylation | Uniprot | |
| S214 | Phosphorylation | Uniprot | |
| S215 | Phosphorylation | Uniprot |
研究背景
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
Fatty acylated. Heavily palmitoylated in the cysteine string motif.
Phosphorylated, mainly on serine residues.
Membrane>Lipid-anchor.
Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
Interacts with GIPC PDZ domain.
限制条款
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