| 产品: | 磷酸化 LAB (Tyr136) 抗体 |
| 货号: | AF8278 |
| 描述: | Rabbit polyclonal antibody to Phospho-LAB (Tyr136) |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Dog |
| 分子量: | 26KD; 27kD(Calculated). |
| 蛋白号: | Q9GZY6 |
| RRID: | AB_2840340 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF8278, RRID:AB_2840340.
展开/折叠
HSPC046; LAB; LAT2; Linker for activation of B cells; Linker for activation of B-cells; Linker for activation of T cells family member 2; Linker for activation of T cells transmembrane adaptor 2; Linker for activation of T-cells family member 2; Membrane associated adapter molecule; Membrane-associated adapter molecule; Non T cell activation linker; Non-T-cell activation linker; NTAL_HUMAN; WBSCR 5; Wbscr15; Williams Beuren syndrome chromosome region 15; Williams Beuren syndrome chromosome region 5; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein; WSCR5;
抗原和靶标
Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
- Q9GZY6 NTAL_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSSGTELLWPGAALLVLLGVAASLCVRCSRPGAKRSEKIYQQRSLREDQQSFTGSRTYSLVGQAWPGPLADMAPTRKDKLLQFYPSLEDPASSRYQNFSKGSRHGSEEAYIDPIAMEYYNWGRFSKPPEDDDANSYENVLICKQKTTETGAQQEGIGGLCRGDLSLSLALKTGPTSGLCPSASPEEDEESEDYQNSASIHQWRESRKVMGQLQREASPGPVGSPDEEDGEPDYVNGEVAATEA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9GZY6 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y40 | Phosphorylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| S55 | Phosphorylation | Uniprot | |
| T57 | Phosphorylation | Uniprot | |
| Y58 | Phosphorylation | Uniprot | |
| S59 | Phosphorylation | Uniprot | |
| K77 | Ubiquitination | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| Y84 | Phosphorylation | Uniprot | |
| S86 | Phosphorylation | Uniprot | |
| Y95 | Phosphorylation | P07948 (LYN) | Uniprot |
| K100 | Ubiquitination | Uniprot | |
| S102 | Phosphorylation | Uniprot | |
| S106 | Phosphorylation | Uniprot | |
| Y110 | Phosphorylation | P10721 (KIT) , P07948 (LYN) | Uniprot |
| Y118 | Phosphorylation | P10721 (KIT) , P07948 (LYN) | Uniprot |
| Y119 | Phosphorylation | P07948 (LYN) | Uniprot |
| K126 | Ubiquitination | Uniprot | |
| S135 | Phosphorylation | Uniprot | |
| Y136 | Phosphorylation | P07948 (LYN) , P43405 (SYK) | Uniprot |
| S167 | Phosphorylation | Uniprot | |
| S183 | Phosphorylation | Uniprot | |
| S190 | Phosphorylation | Uniprot | |
| Y193 | Phosphorylation | P43405 (SYK) | Uniprot |
| S196 | Phosphorylation | Uniprot | |
| S198 | Phosphorylation | Uniprot | |
| S205 | Phosphorylation | Uniprot | |
| S217 | Phosphorylation | Uniprot | |
| Y233 | Phosphorylation | P43405 (SYK) | Uniprot |
研究背景
Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.
May be polyubiquitinated.
Cell membrane>Single-pass type III membrane protein.
Note: Present in lipid rafts.
Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
When phosphorylated, interacts with GRB2. May also interact with SOS1, GAB1 and CBL.
限制条款
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