| 产品: | 磷酸化 NDRG2 (Thr348) 抗体 |
| 货号: | AF8292 |
| 描述: | Rabbit polyclonal antibody to Phospho-NDRG2 (Thr348) |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 41kDa; 41kD(Calculated). |
| 蛋白号: | Q9UN36 |
| RRID: | AB_2840354 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF8292, RRID:AB_2840354.
展开/折叠
Antidepressant related protein ADRG123; Cytoplasmic protein Ndr1; DKFZp781G1938; FLJ25522; KIAA1248; N myc downstream regulated gene 2; N myc downstream regulator 2; NDR1 related protein NDR2; NDRG 2; NDRG family member 2; NDRG1 related protein; NDRG2; NDRG2_HUMAN; Protein NDRG2; Protein Syld709613; SYLD; Syld709613 protein;
抗原和靶标
Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).
- Q9UN36 NDRG2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLRCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMASSCMTRLSRSRTASLTSAASVDGNRSRSRTLSQSSESGTLSSGPPGHTMEVSC
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9UN36 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| T20 | Phosphorylation | Uniprot | |
| Y47 | Phosphorylation | Uniprot | |
| T57 | Phosphorylation | Uniprot | |
| R247 | Methylation | Uniprot | |
| S276 | Phosphorylation | Uniprot | |
| Y309 | Phosphorylation | Uniprot | |
| S319 | Phosphorylation | Uniprot | |
| T323 | Phosphorylation | Uniprot | |
| S326 | Phosphorylation | Uniprot | |
| S328 | Phosphorylation | Uniprot | |
| T330 | Phosphorylation | O00141 (SGK1) | Uniprot |
| S332 | Phosphorylation | P23443 (RPS6KB1) , O00141 (SGK1) , P31749 (AKT1) , Q15418 (RPS6KA1) | Uniprot |
| T334 | Phosphorylation | Uniprot | |
| S335 | Phosphorylation | Uniprot | |
| S338 | Phosphorylation | Uniprot | |
| S344 | Phosphorylation | Uniprot | |
| S346 | Phosphorylation | O00141 (SGK1) | Uniprot |
| T348 | Phosphorylation | O00141 (SGK1) , P31749 (AKT1) | Uniprot |
| S350 | Phosphorylation | Q15418 (RPS6KA1) , P23443 (RPS6KB1) | Uniprot |
| S352 | Phosphorylation | Uniprot | |
| S353 | Phosphorylation | Uniprot | |
| S355 | Phosphorylation | Uniprot | |
| T357 | Phosphorylation | Uniprot | |
| S359 | Phosphorylation | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| T366 | Phosphorylation | Uniprot | |
| S370 | Phosphorylation | Uniprot |
研究背景
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.
Cytoplasm. Cytoplasm>Perinuclear region. Cell projection>Growth cone.
Note: In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity).
Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).
Interacts with CTNNB1.
Belongs to the NDRG family.
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