Phospho-ETV6 / Tel (Ser257) Antibody - #AF8325
| 产品: | 磷酸化 ETV6 / Tel (Ser257) 抗体 |
| 货号: | AF8325 |
| 描述: | Rabbit polyclonal antibody to Phospho-ETV6 / Tel (Ser257) |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 53 KD; 53kD(Calculated). |
| 蛋白号: | P41212 |
| RRID: | AB_2840387 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF8325, RRID:AB_2840387.
展开/折叠
ETS related protein Tel1; ETS translocation variant 6; Ets variant 6; Ets variant gene 6 (TEL oncogene); ETS-related protein Tel1; ETV 6; ETV6; ETV6_HUMAN; Tel; TEL oncogene; TEL/ABL; TEL1; TEL1 oncogene; Transcription factor ETV 6; Transcription factor ETV6;
抗原和靶标
- P41212 ETV6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVYQLLSDSRYENFIRWEDKESKIFRIVDPNGLARLWGNHKNRTNMTYEKMSRALRHYYKLNIIRKEPGQRLLFRFMKTPDEIMSGRTDRLEHLESQELDEQIYQEDEC
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P41212 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| T4 | Phosphorylation | Uniprot | |
| K11 | Acetylation | Uniprot | |
| K11 | Sumoylation | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| Y17 | Phosphorylation | Uniprot | |
| T18 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Q16539 (MAPK14) | Uniprot |
| S26 | Phosphorylation | Uniprot | |
| Y27 | Phosphorylation | Uniprot | |
| S29 | Phosphorylation | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| T31 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| Y60 | Phosphorylation | Uniprot | |
| K99 | Sumoylation | Uniprot | |
| S131 | Phosphorylation | Uniprot | |
| S139 | Phosphorylation | Uniprot | |
| T142 | Phosphorylation | Uniprot | |
| T161 | Phosphorylation | Uniprot | |
| S165 | Phosphorylation | Uniprot | |
| S182 | Phosphorylation | Uniprot | |
| S184 | Phosphorylation | Uniprot | |
| T187 | Phosphorylation | Uniprot | |
| T188 | Phosphorylation | Uniprot | |
| S193 | Phosphorylation | Uniprot | |
| S203 | Phosphorylation | Uniprot | |
| S213 | Phosphorylation | P27361 (MAPK3) | Uniprot |
| S238 | Phosphorylation | Uniprot | |
| S257 | Phosphorylation | Q16539 (MAPK14) , P27361 (MAPK3) | Uniprot |
| S271 | Phosphorylation | Uniprot | |
| S284 | Phosphorylation | Uniprot | |
| S293 | Phosphorylation | Uniprot | |
| K302 | Acetylation | Uniprot | |
| K302 | Ubiquitination | Uniprot | |
| Y314 | Phosphorylation | Uniprot | |
| S323 | Phosphorylation | Uniprot | |
| K384 | Ubiquitination | Uniprot | |
| K393 | Ubiquitination | Uniprot | |
| Y401 | Phosphorylation | Uniprot | |
| Y402 | Phosphorylation | Uniprot | |
| K403 | Ubiquitination | Uniprot | |
| K421 | Sumoylation | Uniprot | |
| K421 | Ubiquitination | Uniprot | |
| T422 | Phosphorylation | Uniprot | |
| S439 | Phosphorylation | Uniprot | |
| Y447 | Phosphorylation | Uniprot |
研究背景
Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.
Phosphorylation of Ser-257 by MAPK14 (p38) inhibits ETV6 transcriptional repression.
Nucleus.
Ubiquitous.
Can form homodimers or heterodimers with TEL2 or FLI1. Interacts with L3MBTL1 and HDAC9.
Belongs to the ETS family.
研究领域
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
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