Phospho-ROR2 (Ser449) Antibody - #AF8451

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产品: 磷酸化 ROR2 (Ser449) 抗体
货号: AF8451
描述: Rabbit polyclonal antibody to Phospho-ROR2 (Ser449)
应用: WB
反应: Human, Mouse
预测: Pig, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 105kDa; 105kD(Calculated).
蛋白号: Q01974
RRID: AB_2840506

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   规格 价格 库存
 100ul RMB¥ 2800 现货
 200ul RMB¥ 3800 现货

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产品描述

来源:
Rabbit
应用:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Pig(89%), Horse(89%), Sheep(89%), Rabbit(100%), Dog(89%), Chicken(100%), Xenopus(100%)
克隆:
Polyclonal
特异性:
Phospho-ROR2 (Ser449) Antibody detects endogenous levels of ROR2 only when phosphorylated at Ser449.
RRID:
AB_2840506
引用格式: Affinity Biosciences Cat# AF8451, RRID:AB_2840506.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

BDB; BDB1; Brachydactyly type B; EC 2.7.10.1; MGC163394; Neurotrophic tyrosine kinase; Neurotrophic tyrosine kinase, receptor related 2; NTRKR2; Receptor tyrosine kinase-like orphan receptor 2; receptor-related 2; ROR2; ROR2_HUMAN; Tyrosine protein kinase transmembrane receptor ROR2; Tyrosine-protein kinase transmembrane receptor Ror2;

抗原和靶标

免疫原:
Uniprot:

Q01974(ROR2_HUMAN) >>Visit HPA database.

基因/基因ID:
ROR2(4920)
序列:
MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNAPEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Xenopus
100
Chicken
100
Rabbit
100
Pig
89
Horse
89
Sheep
89
Dog
89
Zebrafish
78
Bovine
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q01974 作为底物

Site PTM Type Enzyme
K97 Ubiquitination
T157 O-Glycosylation
T438 Phosphorylation
S447 Phosphorylation
S449 Phosphorylation
K466 Ubiquitination
S469 Phosphorylation
K489 Ubiquitination
K507 Ubiquitination
K512 Ubiquitination
Y555 Phosphorylation
Y624 Phosphorylation
K626 Ubiquitination
Y645 Phosphorylation
Y646 Phosphorylation
K647 Ubiquitination
Y666 Phosphorylation
Y755 Phosphorylation
S758 Phosphorylation
S762 Phosphorylation
S782 Phosphorylation
K792 Ubiquitination
Y824 Phosphorylation
S864 Phosphorylation P49841 (GSK3B)
Y873 Phosphorylation

研究背景

功能:

Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.

细胞定位:

Cell membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Homodimer; promotes osteogenesis. Binds YWHAB. Interacts with WTIP (By similarity).

蛋白家族:

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.

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