Phospho-CBX1 / HP1 beta (Thr51) Antibody - #AF8483
| 产品: | 磷酸化 CBX1 / HP1 beta (Thr51) 抗体 |
| 货号: | AF8483 |
| 描述: | Rabbit polyclonal antibody to Phospho-CBX1 / HP1 beta (Thr51) |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 25 kDa; 21kD(Calculated). |
| 蛋白号: | P83916 |
| RRID: | AB_2840537 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF8483, RRID:AB_2840537.
展开/折叠
CBX 1; CBX; Cbx1; CBX1_HUMAN; Chromobox 1; Chromobox homolog 1 (HP1 beta homolog Drosophila ); chromobox homolog 1; Chromobox protein homolog 1; Drosophila HP1 beta; Heterochromatin protein 1 beta; Heterochromatin protein 1 homolog beta; Heterochromatin protein p25; heterochromatin protein p25 beta; HP1 beta; HP1 beta homolog; HP1 beta homolog Drosophila; HP1, Drosophila. homolog of, beta; HP1beta; HP1Hs beta; HP1Hsbeta; Human heterochromatin protein p25 mRNA complete cds; M31; MOD 1; MOD1; Modifier 1 protein; p25beta;
抗原和靶标
- P83916 CBX1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDCPDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKPRGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHSYPSEDDDKKDDKN
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P83916 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K9 | Acetylation | Uniprot | |
| K9 | Methylation | Uniprot | |
| K9 | Ubiquitination | Uniprot | |
| Y21 | Phosphorylation | Uniprot | |
| K25 | Ubiquitination | Uniprot | |
| K33 | Acetylation | Uniprot | |
| K35 | Acetylation | Uniprot | |
| K35 | Methylation | Uniprot | |
| K35 | Ubiquitination | Uniprot | |
| K41 | Acetylation | Uniprot | |
| K41 | Ubiquitination | Uniprot | |
| K43 | Ubiquitination | Uniprot | |
| T51 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| S70 | Phosphorylation | Uniprot | |
| K72 | Ubiquitination | Uniprot | |
| T73 | Phosphorylation | Uniprot | |
| T77 | Phosphorylation | Uniprot | |
| S80 | Phosphorylation | Uniprot | |
| K84 | Acetylation | Uniprot | |
| K84 | Ubiquitination | Uniprot | |
| S89 | Phosphorylation | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| S98 | Phosphorylation | Uniprot | |
| K104 | Ubiquitination | Uniprot | |
| K109 | Ubiquitination | Uniprot | |
| R111 | Methylation | Uniprot | |
| R115 | Methylation | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| K139 | Acetylation | Uniprot | |
| K139 | Ubiquitination | Uniprot | |
| K150 | Ubiquitination | Uniprot | |
| K155 | Ubiquitination | Uniprot | |
| C156 | S-Nitrosylation | Uniprot | |
| S172 | Phosphorylation | Uniprot | |
| Y173 | Phosphorylation | Uniprot | |
| S175 | Phosphorylation | Uniprot | |
| K180 | Ubiquitination | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| K184 | Ubiquitination | Uniprot |
研究背景
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
Not phosphorylated.
Ubiquitinated.
Nucleus.
Note: Unassociated with chromosomes during mitosis.
Expressed in all adult and embryonic tissues.
Homodimer (By similarity). Interacts directly with CHAF1A, EMSY, LBR, TIF1/TIF1A and TRIM28/TIF1B PXVXL motif via the chromoshadow domain. Interacts directly with histone H3 methylated at 'Lys-9' via the chromo domain (By similarity). Interacts with SUV39H1 and SETDB1, KMT5B and KMT5C. Interacts with PRDM6 (By similarity). Interacts with POGZ. Interacts with CHAMP1. Interacts with INCENP. Interacts with SGO1; the CBX1 homodimer binds to one molecule of SGO1. Interacts with LRIF1 (via PxVxL motif).
限制条款
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