Phospho-STYK1/NOK (Tyr327) Antibody - #AF8513
| 产品: | 磷酸化 STYK1/NOK (Tyr327) 抗体 |
| 货号: | AF8513 |
| 描述: | Rabbit polyclonal antibody to Phospho-STYK1/NOK (Tyr327) |
| 应用: | WB |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| 分子量: | 47kDa; 48kD(Calculated). |
| 蛋白号: | Q6J9G0 |
| RRID: | AB_2840567 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF8513, RRID:AB_2840567.
展开/折叠
DKFZp761P1010; NOK; Novel oncogene with kinase domain; Protein kinase STYK1; Protein PK unique; Protein PK-unique; Serine/threonine/tyrosine kinase 1; Styk 1; STYK1; STYK1_HUMAN; SuRTK 106; SuRTK106; Tyrosine protein kinase STYK1; Tyrosine-protein kinase STYK1;
抗原和靶标
Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most normal lung tissues, widely expressed in lung cancers.
- Q6J9G0 STYK1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSGPQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYSML
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q6J9G0 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S59 | Phosphorylation | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| T90 | Phosphorylation | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| Y221 | Phosphorylation | Uniprot | |
| T224 | Phosphorylation | Uniprot |
研究背景
Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).
Membrane>Single-pass membrane protein.
Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most normal lung tissues, widely expressed in lung cancers.
Belongs to the protein kinase superfamily. Tyr protein kinase family.
限制条款
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