Phospho-p57 Kip2 (Thr310) Antibody - #DF2992
| 产品: | 磷酸化 p57 Kip2 (Thr310) 抗体 |
| 货号: | DF2992 |
| 描述: | Rabbit polyclonal antibody to Phospho-p57 Kip2 (Thr310) |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Pig, Bovine, Sheep |
| 分子量: | 57 KD; 32kD(Calculated). |
| 蛋白号: | P49918 |
| RRID: | AB_2840971 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF2992, RRID:AB_2840971.
展开/折叠
Beckwith Wiedemann syndrome; BWCR; BWS; CDKI; CDKN 1C; CDKN1C; CDN1C_HUMAN; Cyclin dependent kinase inhibitor 1C; Cyclin dependent kinase inhibitor p57; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; KIP 2; KIP2; p57; p57 Kip 2; p57KIP2; WBS;
抗原和靶标
Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.
- P49918 CDN1C_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSDASLRSTSTMERLVARGTFPVLVRTSACRSLFGPVDHEELSRELQARLAELNAEDQNRWDYDFQQDMPLRGPGRLQWTEVDSDSVPAFYRETVQVGRCRLLLAPRPVAVAVAVSPPLEPAAESLDGLEEAPEQLPSVPVPAPASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAVLAPAPAPAPAPAPAPAPVAAPAPAPAPAPAPAPAPAPAPDAAPQESAEQGANQGQRGQEPLADQLHSGISGRPAAGTAAASANGAAIKKLSGPLISDFFAKRKRSAPEKSSGDVPAPCPSPSAAPGVGSVEQTPRKRLR
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P49918 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S43 | Phosphorylation | Uniprot | |
| S146 | Phosphorylation | Q16539 (MAPK14) | Uniprot |
| K266 | Acetylation | Uniprot | |
| S268 | Phosphorylation | Uniprot | |
| K278 | Acetylation | Uniprot | |
| S282 | Phosphorylation | P31749 (AKT1) | Uniprot |
| S297 | Phosphorylation | Uniprot | |
| S299 | Phosphorylation | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| T310 | Phosphorylation | P31749 (AKT1) | Uniprot |
研究背景
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
Nucleus.
Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.
Interacts with PCNA.
Belongs to the CDI family.
研究领域
· Cellular Processes > Cell growth and death > Cell cycle. (View pathway)
限制条款
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