| 产品: | DCLK1 抗体 |
| 货号: | DF8307 |
| 描述: | Rabbit polyclonal antibody to DCLK1 |
| 应用: | WB |
| 反应: | Human, Mouse |
| 预测: | Pig |
| 分子量: | 82 kDa; 82kD(Calculated). |
| 蛋白号: | O15075 |
| RRID: | AB_2841589 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8307, RRID:AB_2841589.
展开/折叠
Calcium/calmodulin-dependent protein kinase type I-like CPG16; CL1; CLICK1; Cpg16; DCDC3A; Dcl; Dclk; Dclk1; DCLK1_HUMAN; Doublecortin domain-containing protein 3A; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1; KIAA0369; Serine/threonine-protein kinase DCAMKL1; Serine/threonine-protein kinase DCLK1;
抗原和靶标
In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain.
- O15075 DCLK1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGSPSEVRENKDFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRYQDDFLLDESECRVVKSTSYTKIASSSRRSTTKSPGPSRRSKSPASTSSVNGTPGSQLSTPRSGKSPSPSPTSPGSLRKQRSSQHGGSSTSLASTKVCSSMDENDGPGEEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHFNTGPKPNSTAAGVSVIATTALDKERQVFRRRRNQDVRSRYKAQPAPPELNSESEDYSPSSSETVRSPNSPF
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O15075 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| T34 | Phosphorylation | Uniprot | |
| S36 | Phosphorylation | Uniprot | |
| T46 | Phosphorylation | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| S164 | Phosphorylation | Uniprot | |
| S172 | Phosphorylation | Uniprot | |
| Y265 | Phosphorylation | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| K280 | Ubiquitination | Uniprot | |
| S298 | Phosphorylation | Uniprot | |
| S305 | Phosphorylation | Uniprot | |
| S307 | Phosphorylation | Uniprot | |
| S312 | Phosphorylation | Uniprot | |
| S313 | Phosphorylation | Uniprot | |
| T324 | Phosphorylation | Uniprot | |
| S327 | Phosphorylation | Uniprot | |
| S330 | Phosphorylation | Uniprot | |
| S332 | Phosphorylation | Uniprot | |
| S334 | Phosphorylation | Uniprot | |
| T336 | Phosphorylation | Uniprot | |
| S337 | Phosphorylation | Uniprot | |
| S340 | Phosphorylation | Uniprot | |
| S352 | Phosphorylation | Uniprot | |
| S353 | Phosphorylation | Uniprot | |
| S358 | Phosphorylation | Uniprot | |
| S489 | Phosphorylation | Uniprot | |
| Y493 | Phosphorylation | Uniprot | |
| S720 | Phosphorylation | Uniprot | |
| S726 | Phosphorylation | Uniprot | |
| S729 | Phosphorylation | Uniprot | |
| S738 | Phosphorylation | Uniprot |
研究背景
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain.
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
限制条款
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