产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8742, RRID:AB_2841946.
展开/折叠
2210022N24Rik; 2810422B09Rik; AI462649; AW209236; KIAA1101; mKIAA1101; OSR 1; OSR1; OTTHUMP00000209062; Oxidative stress responsive 1; Oxidative stress responsive 1 protein; Oxidative stress-responsive 1 protein; OXSR 1; OXSR1; OXSR1_HUMAN; Serine/threonine protein kinase OSR1; Serine/threonine-protein kinase OSR1;
抗原和靶标
- O95747 OXSR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTLQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKESISNSELFPTTDPVGTLLQVPEQISAHLPQPAGQIATQPTQVSLPPTAEPAKTAQALSSGSGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O95747 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | Uniprot | |
| K42 | Acetylation | Uniprot | |
| K46 | Acetylation | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| K114 | Ubiquitination | Uniprot | |
| K139 | Ubiquitination | Uniprot | |
| K184 | Ubiquitination | Uniprot | |
| T185 | Phosphorylation | Q9H4A3 (WNK1) | Uniprot |
| T189 | Phosphorylation | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| S263 | Phosphorylation | Uniprot | |
| S269 | Phosphorylation | Uniprot | |
| K278 | Ubiquitination | Uniprot | |
| R287 | Methylation | Uniprot | |
| K297 | Methylation | Uniprot | |
| K303 | Ubiquitination | Uniprot | |
| T310 | Phosphorylation | Uniprot | |
| S312 | Phosphorylation | Uniprot | |
| S324 | Phosphorylation | Uniprot | |
| S325 | Phosphorylation | Q9H4A3 (WNK1) | Uniprot |
| T331 | Phosphorylation | Uniprot | |
| S339 | Phosphorylation | P42345 (MTOR) | Uniprot |
| S347 | Phosphorylation | Uniprot | |
| S355 | Phosphorylation | Uniprot | |
| S359 | Phosphorylation | Uniprot | |
| S369 | Phosphorylation | Uniprot | |
| S425 | Phosphorylation | Uniprot | |
| S427 | Phosphorylation | Uniprot | |
| T430 | Phosphorylation | Uniprot | |
| S435 | Phosphorylation | Uniprot | |
| S443 | Phosphorylation | Uniprot | |
| K444 | Methylation | Uniprot | |
| R451 | Methylation | Uniprot | |
| S510 | Phosphorylation | Uniprot |
翻译修饰 - O95747 作为激酶
| Substrate | Site | Source |
|---|---|---|
| P55011 (SLC12A2) | T203 | Uniprot |
| P55011 (SLC12A2) | T207 | Uniprot |
| P55011 (SLC12A2) | T212 | Uniprot |
| P55011 (SLC12A2) | T217 | Uniprot |
| P55011 (SLC12A2) | T230 | Uniprot |
| P55017 (SLC12A3) | T46 | Uniprot |
| P55017 (SLC12A3) | T55 | Uniprot |
| P55017 (SLC12A3) | T60 | Uniprot |
| P55017 (SLC12A3) | S73 | Uniprot |
| Q13153 (PAK1) | T84 | Uniprot |
| Q13621 (SLC12A1) | T95 | Uniprot |
| Q13621 (SLC12A1) | T100 | Uniprot |
| Q13621 (SLC12A1) | T105 | Uniprot |
| Q13621 (SLC12A1) | T118 | Uniprot |
| Q13621 (SLC12A1) | S120 | Uniprot |
研究背景
Phosphorylates RELL1, RELL2 and RELT. Phosphorylates PAK1. Phosphorylates PLSCR1 in the presence of RELT.
Autophosphorylated.
Cytoplasm.
Ubiquitously expressed in all tissue examined.
Interacts with PAK1. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress (By similarity). Interacts with RELL1, RELL2 and RELT. Interacts with PLSCR1 in the presence of RELT.
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
限制条款
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