| 产品: | 磷酸化 TFAP2C (Ser434) 抗体 |
| 货号: | AF7082 |
| 描述: | Rabbit polyclonal antibody to Phospho-TFAP2C (Ser434) |
| 应用: | WB |
| 反应: | Human, Mouse |
| 预测: | Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 49kDa; 49kD(Calculated). |
| 蛋白号: | Q92754 |
| RRID: | AB_2843522 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF7082, RRID:AB_2843522.
展开/折叠
Activating enhancer binding protein 2 gamma; Activating enhancer-binding protein 2 gamma; AP2-gamma; AP2C_HUMAN; AP2g; AP2gamma; ERF 1; ERF1; Estrogen receptor factor 1; hAP 2g; hAP2g; TFAP 2C; TFAP 2G; Tfap2c; TFAP2G; Transcription factor AP 2 gamma (activating enhancer binding protein 2 gamma); Transcription factor AP 2 gamma; Transcription factor AP-2 gamma; Transcription factor ERF 1; Transcription factor ERF-1; Transcription factor ERF1;
抗原和靶标
- Q92754 AP2C_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLWKITDNVKYEEDCEDRHDGSSNGNPRVPHLSSAGQHLYSPAPPLSHTGVAEYQPPPYFPPPYQQLAYSQSADPYSHLGEAYAAAINPLHQPAPTGSQQQAWPGRQSQEGAGLPSHHGRPAGLLPHLSGLEAGAVSARRDAYRRSDLLLPHAHALDAAGLAENLGLHDMPHQMDEVQNVDDQHLLLHDQTVIRKGPISMTKNPLNLPCQKELVGAVMNPTEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAHVTLLTSLVEGEAVHLARDFAYVCEAEFPSKPVAEYLTRPHLGGRNEMAARKNMLLAAQQLCKEFTELLSQDRTPHGTSRLAPVLETNIQNCLSHFSLITHGFGSQAICAAVSALQNYIKEALIVIDKSYMNPGDQSPADSNKTLEKMEKHRK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q92754 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K10 | Sumoylation | Uniprot | |
| K202 | Ubiquitination | Uniprot | |
| S236 | Phosphorylation | Uniprot | |
| S238 | Phosphorylation | Uniprot | |
| K239 | Ubiquitination | Uniprot | |
| K241 | Ubiquitination | Uniprot | |
| S252 | Phosphorylation | Uniprot | |
| K281 | Ubiquitination | Uniprot | |
| K284 | Ubiquitination | Uniprot | |
| S434 | Phosphorylation | Uniprot | |
| S438 | Phosphorylation | Uniprot | |
| K444 | Ubiquitination | Uniprot | |
| K447 | Ubiquitination | Uniprot |
研究背景
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Sumoylated on Lys-10; which inhibits transcriptional activity.
Nucleus.
Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity). Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Interacts with MTA1.
The PPxY motif mediates interaction with WWOX.
Belongs to the AP-2 family.
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