| 产品: | 磷酸化 HBP1 (Ser380) 抗体 |
| 货号: | AF7132 |
| 描述: | Rabbit polyclonal antibody to Phospho-HBP1 (Ser380) |
| 应用: | WB |
| 反应: | Human |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 58kDa; 58kD(Calculated). |
| 蛋白号: | O60381 |
| RRID: | AB_2843572 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF7132, RRID:AB_2843572.
展开/折叠
FLJ16340; HBP 1; HBP1; HBP1_HUMAN; High mobility group box transcription factor 1; HMG box containing protein 1; HMG box transcription factor 1; HMG box-containing protein 1;
抗原和靶标
- O60381 HBP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSGMYQLSSDVSHQEYPRSSWNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHERANSESESGIFCMSSLSDDDDLGWCNSWPSTVWHCFLKGTRLCFHKGSNKEWQDVEDFARAEGCDNEEDLQMGIHKGYGSDGLKLLSHEESVSFGESVLKLTFDPGTVEDGLLTVECKLDHPFYVKNKGWSSFYPSLTVVQHGIPCCEVHIGDVCLPPGHPDAINFDDSGVFDTFKSYDFTPMDSSAVYVLSSMARQRRASLSCGGPGGQDFARSGFSKNCGSPGSSQLSSNSLYAKAVKNHSSGTVSATSPNKCKRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKNEERRMYTLEAKALAEEQKRLNPDCWKRKRTNSGSQQH
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O60381 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K16 | Ubiquitination | Uniprot | |
| K23 | Ubiquitination | Uniprot | |
| S135 | Phosphorylation | Uniprot | |
| S156 | Phosphorylation | Uniprot | |
| S157 | Phosphorylation | Uniprot | |
| S158 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| K171 | Acetylation | Uniprot | |
| K225 | Ubiquitination | Uniprot | |
| K229 | Ubiquitination | Uniprot | |
| K255 | Ubiquitination | Uniprot | |
| K263 | Ubiquitination | Uniprot | |
| K297 | Acetylation | Uniprot | |
| K297 | Ubiquitination | Uniprot | |
| K305 | Acetylation | Uniprot | |
| K305 | Ubiquitination | Uniprot | |
| K307 | Acetylation | Uniprot | |
| S372 | Phosphorylation | Uniprot | |
| S380 | Phosphorylation | Uniprot | |
| S382 | Phosphorylation | Uniprot | |
| K398 | Ubiquitination | Uniprot | |
| S402 | Phosphorylation | Q15759 (MAPK11) , Q16539 (MAPK14) | Uniprot |
| K416 | Ubiquitination | Uniprot | |
| K419 | Acetylation | Uniprot | |
| K419 | Ubiquitination | Uniprot | |
| S430 | Phosphorylation | Uniprot | |
| K433 | Ubiquitination | Uniprot | |
| T453 | Phosphorylation | Uniprot | |
| T484 | Phosphorylation | Uniprot | |
| K488 | Ubiquitination | Uniprot | |
| K495 | Ubiquitination | Uniprot | |
| K503 | Ubiquitination | Uniprot | |
| S509 | Phosphorylation | Uniprot |
研究背景
Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.
Ubiquitinated by the CTLH E3 ubiquitin-protein ligase complex, leading to subsequent proteasomal degradation.
Nucleus.
Binds the second PAH repeat of SIN3A (Probable). Binds TCF4. Binds RB1.
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