产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF7415, RRID:AB_2843855.
展开/折叠
B-cell CLL; B-cell CLL/lymphoma 9-like protein; B-cell lymphoma 9-like protein; B9L; BCL9-2; BCL9-like protein; BCL9-related beta-catenin-binding protein; Bcl9l; BCL9L_HUMAN; DLNB11; Nuclear co factor of beta catenin signalling; Protein BCL9-2;
抗原和靶标
Expressed in breast, ductal and invasive ductal carcinomas of the breast, sporadic colorectal adenomas and carcinomas (at protein level). Expressed in fetal brain. Expressed in lung, amygdala, eye, prostate, pancreatic and prostate cancers, head and neck tumors and embryonal tumor.
- Q86UU0 BCL9L_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRILANKTRLPHPRRREAPGSPPLSPRGHCPPAPAKPMHPENKLTNHGKTGNGGAQSQHQNVNQGPTCNVGSKGVGAGNHGAKANQISPSNSSLKNPQAGVPPFSSLKGKVKRDRSVSVDSGEQREAGTPSLDSEAKEVAPRSKRRCVLERKQPYSGDEWCSGPDSEEDDKPIGATHNCNVADPAMAAPQLGPGQTTQLPLSESSVPGAPHGPPPGLRPDAPGGGGGGGGVPGKPPSQFVYVFTTHLANTAAEAVLQGRADSILAYHQQNVPRAKLDQAPKVPPTPEPLPLSTPSAGTPQSQPPPLPPPPPPAPGSAPPALPPEGPPEDSSQDLAPNSVGAASTGGGTGGTHPNTPTATTANNPLPPGGDPSSAPGPALLGEAAAPGNGQRSLVGSEGLSKEQLEHRERSLQTLRDIERLLLRSGETEPFLKGPPGGAGEGGPPAQAPPPPQQPPTAPPSGLKKYEEPLQSMISQTQSLGGPPLEHEVPGHPPGGDMGQQMNMMIQRLGQDSLTPEQVAWRKLQEEYYEEKRRKEEQIGLHGSRPLQDMMGMGGMMVRGPPPPYHSKPGDQWPPGMGAQLRGPMDVQDPMQLRGGPPFPGPRFPGNQIQRVPGFGGMQSMPMEVPMNAMQRPVRPGMGWTEDLPPMGGPSNFAQNTMPYPGGQGEAERFMTPRVREELLRHQLLEKRSMGMQRPLGMAGSGMGQSMEMERMMQAHRQMDPAMFPGQMAGGEGLAGTPMGMEFGGGRGLLSPPMGQSGLREVDPPMGPGNLNMNMNVNMNMNMNLNVQMTPQQQMLMSQKMRGPGDLMGPQGLSPEEMARVRAQNSSGVMGGPQKMLMPSQFPNQGQQGFSGGQGPYQAMSQDMGNTQDMFSPDQSSMPMSNVGTTRLSHMPLPPASNPPGTVHSAPNRGLGRRPSDLTISINQMGSPGMGHLKSPTLSQVHSPLVTSPSANLKSPQTPSQMVPLPSANPPGPLKSPQVLGSSLSVRSPTGSPSRLKSPSMAVPSPGWVASPKTAMPSPGVSQNKQPPLNMNSSTTLSNMEQGTLPPSGPRSSSSAPPANPPSGLMNPSLPFTSSPDPTPSQNPLSLMMTQMSKYAMPSSTPLYHNAIKTIATSDDELLPDRPLLPPPPPPQGSGPGISNSQPSQMHLNSAAAQSPMGMNLPGQQPLSHEPPPAMLPSPTPLGSNIPLHPNAQGTGGPPQNSMMMAPGGPDSLNAPCGPVPSSSQMMPFPPRLQQPHGAMAPTGGGGGGPGLQQHYPSGMALPPEDLPNQPPGPMPPQQHLMGKAMAGRMGDAYPPGVLPGVASVLNDPELSEVIRPTPTGIPEFDLSRIIPSEKPSSTLQYFPKSENQPPKAQPPNLHLMNLQNMMAEQTPSRPPNLPGQQGVQRGLNMSMCHPGQMSLLGRTGVPPQQGMVPHGLHQGVMSPPQGLMTQQNFMLMKQRGVGGEVYSQPPHMLSPQGSLMGPPPQQNLMVSHPLRQRSVSLDSQMGYLPAPGGMANLPF
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q86UU0 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S21 | Phosphorylation | Uniprot | |
| S25 | Phosphorylation | Uniprot | |
| K36 | Acetylation | Uniprot | |
| K43 | Acetylation | Uniprot | |
| K49 | Acetylation | Uniprot | |
| C68 | S-Nitrosylation | Uniprot | |
| K73 | Acetylation | Uniprot | |
| K83 | Acetylation | Uniprot | |
| S88 | Phosphorylation | Uniprot | |
| S93 | Phosphorylation | Uniprot | |
| S105 | Phosphorylation | Uniprot | |
| S106 | Phosphorylation | Uniprot | |
| K108 | Acetylation | Uniprot | |
| K110 | Acetylation | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| S121 | Phosphorylation | Uniprot | |
| T129 | Phosphorylation | Uniprot | |
| K137 | Acetylation | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| K401 | Ubiquitination | Uniprot | |
| S410 | Phosphorylation | Uniprot | |
| S424 | Phosphorylation | Uniprot | |
| Y465 | Phosphorylation | Uniprot | |
| T514 | Phosphorylation | Uniprot | |
| K522 | Sumoylation | Uniprot | |
| Y527 | Phosphorylation | Uniprot | |
| K531 | Ubiquitination | Uniprot | |
| K534 | Acetylation | Uniprot | |
| R593 | Methylation | Uniprot | |
| R602 | Methylation | Uniprot | |
| R610 | Methylation | Uniprot | |
| R668 | Methylation | Uniprot | |
| R675 | Methylation | Uniprot | |
| R680 | Methylation | Uniprot | |
| S750 | Phosphorylation | Uniprot | |
| S813 | Phosphorylation | Uniprot | |
| R821 | Methylation | Uniprot | |
| S915 | Phosphorylation | Uniprot | |
| T918 | Phosphorylation | Uniprot | |
| S926 | Phosphorylation | Uniprot | |
| S934 | Phosphorylation | Uniprot | |
| T936 | Phosphorylation | Uniprot | |
| S938 | Phosphorylation | Uniprot | |
| S942 | Phosphorylation | Uniprot | |
| T946 | Phosphorylation | Uniprot | |
| S947 | Phosphorylation | Uniprot | |
| S949 | Phosphorylation | Uniprot | |
| S954 | Phosphorylation | Uniprot | |
| T957 | Phosphorylation | Uniprot | |
| S959 | Phosphorylation | Uniprot | |
| S975 | Phosphorylation | Uniprot | |
| S987 | Phosphorylation | Uniprot | |
| T989 | Phosphorylation | Uniprot | |
| S991 | Phosphorylation | Uniprot | |
| S993 | Phosphorylation | Uniprot | |
| S997 | Phosphorylation | Uniprot | |
| S999 | Phosphorylation | Uniprot | |
| S1004 | Phosphorylation | Uniprot | |
| S1010 | Phosphorylation | Uniprot | |
| T1013 | Phosphorylation | Uniprot | |
| S1017 | Phosphorylation | Uniprot | |
| S1021 | Phosphorylation | Uniprot | |
| K1334 | Acetylation | Uniprot | |
| K1344 | Sumoylation | Uniprot | |
| R1439 | Methylation | Uniprot | |
| Y1446 | Phosphorylation | Uniprot | |
| S1447 | Phosphorylation | Uniprot | |
| S1454 | Phosphorylation | Uniprot | |
| S1458 | Phosphorylation | Uniprot | |
| S1478 | Phosphorylation | Uniprot | |
| S1480 | Phosphorylation | Uniprot |
研究背景
Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity).
Nucleus.
Expressed in breast, ductal and invasive ductal carcinomas of the breast, sporadic colorectal adenomas and carcinomas (at protein level). Expressed in fetal brain. Expressed in lung, amygdala, eye, prostate, pancreatic and prostate cancers, head and neck tumors and embryonal tumor.
Found in a complex with CDC73; CTNNB1 and PYGO1. Interacts with CTNNB1.
Tne C-terminal domain is important for its transactivation activity.
Belongs to the BCL9 family.
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