产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF4322, RRID:AB_2844401.
展开/折叠
Adapter protein GRID; GADS; GADS protein; GRAP-2; Grap2; GRAP2_HUMAN; GRB-2-like protein; GRB2-related adapter protein 2; GRB2-related adaptor protein 2; GRB2-related protein with insert domain; GRB2L; GRBLG; GRBX; Grf-40; Grf40 adapter protein; Grf40; GRID; Growth factor receptor-binding protein; Growth factor receptor-bound protein 2-related adaptor protein 2; GRPL; Hema; Hematopoietic cell-associated adapter protein GrpL; Hematopoietic cell-associated adaptor protein GRPL; Mona; p38; Protein GADS; SH3-SH2-SH3 adapter Mona; SH3-SH2-SH3 adaptor molecule;
抗原和靶标
- O75791 GRAP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAELGSQEGYVPKNFIDIQFPKWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEEIRPSMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLDINDGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPMTR
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O75791 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K36 | Ubiquitination | Uniprot | |
| S41 | Phosphorylation | Uniprot | |
| Y45 | Phosphorylation | Uniprot | |
| K48 | Ubiquitination | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| K106 | Acetylation | Uniprot | |
| K112 | Ubiquitination | Uniprot | |
| K121 | Ubiquitination | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| Y131 | Phosphorylation | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| S164 | Phosphorylation | Uniprot | |
| S181 | Phosphorylation | Uniprot | |
| S187 | Phosphorylation | Uniprot | |
| T192 | Phosphorylation | Uniprot | |
| Y207 | Phosphorylation | Uniprot | |
| Y222 | Phosphorylation | Uniprot | |
| R233 | Methylation | Uniprot | |
| S236 | Phosphorylation | Uniprot | |
| T246 | Phosphorylation | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| T262 | Phosphorylation | Uniprot | |
| Y324 | Phosphorylation | Uniprot |
研究背景
Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
Nucleus. Cytoplasm. Endosome.
Interacts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB. Interacts with PTPN23.
Belongs to the GRB2/sem-5/DRK family.
研究领域
· Organismal Systems > Immune system > T cell receptor signaling pathway. (View pathway)
限制条款
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