Phospho-GIT2 (Tyr592) Antibody - #AF4472

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产品: 磷酸化 GIT2 (Tyr592) 抗体
货号: AF4472
描述: Rabbit polyclonal antibody to Phospho-GIT2 (Tyr592)
应用: WB IHC
反应: Human
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 84kDa; 85kD(Calculated).
蛋白号: Q14161
RRID: AB_2844526

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
预测:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%)
克隆:
Polyclonal
特异性:
Phospho-GIT2 (Tyr592) Antibody detects endogenous levels of GIT2 only when phosphorylated at Tyr592.
RRID:
AB_2844526
引用格式: Affinity Biosciences Cat# AF4472, RRID:AB_2844526.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

ARF GAP GIT2; ARF GTPase activating protein GIT2; ARF GTPase-activating protein GIT2; CAT 2; CAT-2; CAT2; Cool associated tyrosine phosphorylated protein 2; Cool interacting tyrosine phosphorylated protein 2; Cool-interacting tyrosine-phosphorylated protein 2; DKFZp686G01261; G protein coupled receptor kinase interacting ArfGAP 2; G protein coupled receptor kinase interactor 2; G protein-coupled receptor kinase-interactor 2; GIT 2; GIT2; GIT2_HUMAN; GRK interacting protein 2; GRK-interacting protein 2; KIAA0148; MGC760;

抗原和靶标

免疫原:
Uniprot:

Q14161(GIT2_HUMAN) >>Visit HPA database.

基因/基因ID:
GIT2(9815)
序列:
MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPDHKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDLSDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLQTLQSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPEESRMRLQPFPAHIGRSALVTSSSSLPSFPSTLSWSRDESARRASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENNN

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Xenopus
73
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q14161 作为底物

Site PTM Type Enzyme
S7 Phosphorylation
S8 Phosphorylation
S36 Phosphorylation
K98 Ubiquitination
K103 Ubiquitination
S127 Phosphorylation
K131 Ubiquitination
K135 Ubiquitination
S154 Phosphorylation
T195 Phosphorylation Q13315 (ATM)
Y286 Phosphorylation
S361 Phosphorylation
S365 Phosphorylation
K366 Ubiquitination
T375 Phosphorylation
S381 Phosphorylation
S384 Phosphorylation Q13315 (ATM)
Y392 Phosphorylation
S394 Phosphorylation
S397 Phosphorylation
T401 Phosphorylation
T405 Phosphorylation
T406 Phosphorylation
S408 Phosphorylation
S415 Phosphorylation
S418 Phosphorylation
S421 Phosphorylation
T426 Phosphorylation
K434 Ubiquitination
K443 Ubiquitination
K449 Ubiquitination
K464 Ubiquitination
K477 Ubiquitination
T480 Phosphorylation
T481 Phosphorylation
Y484 Phosphorylation
T488 Phosphorylation
S490 Phosphorylation
Y492 Phosphorylation
T493 Phosphorylation
T495 Phosphorylation
S496 Phosphorylation
S500 Phosphorylation
S506 Phosphorylation
S510 Phosphorylation
S514 Phosphorylation
Y516 Phosphorylation
T518 Phosphorylation
S520 Phosphorylation
Y525 Phosphorylation
S532 Phosphorylation
S557 Phosphorylation
S558 Phosphorylation
S559 Phosphorylation
S562 Phosphorylation
S565 Phosphorylation
S568 Phosphorylation
S570 Phosphorylation
S586 Phosphorylation
T587 Phosphorylation
S590 Phosphorylation
Y592 Phosphorylation
S614 Phosphorylation
S668 Phosphorylation
S673 Phosphorylation
S693 Phosphorylation
T698 Phosphorylation
S699 Phosphorylation
S724 Phosphorylation
K747 Ubiquitination

研究背景

功能:

GTPase-activating protein for the ADP ribosylation factor family.

亚基结构:

Interacts with TGFB1I1 (By similarity). Interacts with G protein-coupled receptor kinases. Associates with paxillin. Also interacts with PIX exchange factors. Identified in a complex with ARHGEF6 and BIN2.

研究领域

· Cellular Processes > Transport and catabolism > Endocytosis.   (View pathway)

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