Phospho-DAPP1/BAM32 (Tyr139) Antibody - #AF4502
| 产品: | 磷酸化 DAPP1/BAM32 (Tyr139) 抗体 |
| 货号: | AF4502 |
| 描述: | Rabbit polyclonal antibody to Phospho-DAPP1/BAM32 (Tyr139) |
| 应用: | WB IHC |
| 反应: | Human, Rat |
| 预测: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 29kDa; 32kD(Calculated). |
| 蛋白号: | Q9UN19 |
| RRID: | AB_2844553 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF4502, RRID:AB_2844553.
展开/折叠
B cell adapter molecule of 32 kDa; B lymphocyte adapter protein Bam32; B-cell adapter molecule of 32 kDa; BAM32; DAPP1; DAPP1_HUMAN; DKFZp667E0716; Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide; Dual adaptor of phosphotyrosine and 3 phosphoinositides; hDAPP1;
抗原和靶标
Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells.
- Q9UN19 DAPP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGRAELLEGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKFGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTAMQTGRTEDDLVPTAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVNCFCLVFPFRTFYLCAKTGVEADEWIKILRWKLSQIRKQLNQGEGTIRSRSFIFK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9UN19 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K132 | Ubiquitination | Uniprot | |
| S137 | Phosphorylation | Uniprot | |
| Y139 | Phosphorylation | P06239 (LCK) , P07948 (LYN) , P12931 (SRC) | Uniprot |
| S141 | Phosphorylation | Uniprot | |
| K167 | Ubiquitination | Uniprot | |
| K173 | Ubiquitination | Uniprot | |
| K182 | Acetylation | Uniprot | |
| K263 | Ubiquitination | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| S276 | Phosphorylation | Uniprot |
研究背景
May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.
Phosphorylated on tyrosine residues.
Cytoplasm. Membrane>Peripheral membrane protein.
Note: Membrane-associated after cell stimulation leading to its translocation.
Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells.
Interacts with PtdIns(3,4,5)P3 and PLCG2. In vitro, interacts with PtdIns(3,4)P2.
研究领域
· Organismal Systems > Immune system > B cell receptor signaling pathway. (View pathway)
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