| 产品: | 磷酸化 OPRK1 (Tyr369) 抗体 |
| 货号: | AF4419 |
| 描述: | Rabbit polyclonal antibody to Phospho-OPRK1 (Tyr369) |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Dog |
| 分子量: | 58kDa; 43kD(Calculated). |
| 蛋白号: | P41145 |
| RRID: | AB_2844629 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF4419, RRID:AB_2844629.
展开/折叠
K-OR-1; Kappa opioid receptor; Kappa type opioid receptor; Kappa-type opioid receptor; KOR 1; KOR; KOR-1; Opiate receptor kappa 1; Opiate receptor, kappa 1; Opioid receptor, kappa 1; OPRK 1; OPRK; OPRK_HUMAN; OPRK1; Oprk2; R21;
抗原和靶标
- P41145 OPRK_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P41145 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N25 | N-Glycosylation | Uniprot | |
| N39 | N-Glycosylation | Uniprot | |
| S260 | Phosphorylation | Uniprot | |
| S262 | Phosphorylation | Uniprot | |
| K338 | Ubiquitination | Uniprot | |
| K349 | Ubiquitination | Uniprot | |
| S358 | Phosphorylation | Q15835 (GRK1) | Uniprot |
| Y369 | Phosphorylation | Calculation | |
| K378 | Ubiquitination | Uniprot |
研究背景
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Cell membrane>Multi-pass membrane protein.
Detected in brain and placenta.
Interacts with SLC9A3R1. Interacts with GABARAPL1.
Belongs to the G-protein coupled receptor 1 family.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
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