Phospho-MUNC-18a (Ser313) Antibody - #AF4451

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产品: 磷酸化 MUNC-18a (Ser313) 抗体
货号: AF4451
描述: Rabbit polyclonal antibody to Phospho-MUNC-18a (Ser313)
应用: WB IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 70kDa; 68kD(Calculated).
蛋白号: P61764
RRID: AB_2844634

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产品描述

来源:
Rabbit
应用:
IF/ICC 1:100-1:500, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(92%), Xenopus(92%)
克隆:
Polyclonal
特异性:
Phospho-MUNC-18a (Ser313) Antibody detects endogenous levels of MUNC-18a only when phosphorylated at Ser313.
RRID:
AB_2844634
引用格式: Affinity Biosciences Cat# AF4451, RRID:AB_2844634.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

FLJ37475; Munc 18 1; Munc 18a; MUNC18 1; N-Sec1; Neuronal SEC1; NSec1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; Rb sec1; RBSEC1; STXB1_HUMAN; STXBP1; Syntaxin binding protein 1; Syntaxin-binding protein 1; Unc 18 homolog; Unc 18A; Unc-18A; Unc18 1; UNC18; Unc18-1;

抗原和靶标

免疫原:
Uniprot:

P61764(STXB1_HUMAN) >>Visit HPA database.

基因/基因ID:
STXBP1(6812)
表达:
P61764 STXB1_HUMAN:

Brain and spinal cord. Highly enriched in axons.

序列:
MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLCATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPQKLLDTLKKLNKTDEEISS

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Xenopus
92
Chicken
92
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P61764 作为底物

Site PTM Type Enzyme
K7 Ubiquitination
K13 Ubiquitination
S70 Phosphorylation
K92 Ubiquitination
Y145 Phosphorylation
K184 Ubiquitination
K196 Ubiquitination
K208 Ubiquitination
K294 Ubiquitination
S306 Phosphorylation
K308 Ubiquitination
S313 Phosphorylation
K314 Ubiquitination
K321 Methylation
K321 Ubiquitination
K332 Ubiquitination
K333 Ubiquitination
Y337 Phosphorylation
K339 Ubiquitination
K364 Ubiquitination
T376 Phosphorylation
K382 Ubiquitination
S454 Phosphorylation
T455 Phosphorylation
Y473 Phosphorylation
T479 Phosphorylation Q13627 (DYRK1A)
T489 Phosphorylation
S507 Phosphorylation
S509 Phosphorylation
S516 Phosphorylation
Y531 Phosphorylation
T574 Phosphorylation
K587 Ubiquitination
S593 Phosphorylation
S594 Phosphorylation

研究背景

功能:

Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.

细胞定位:

Cytoplasm>Cytosol. Membrane>Peripheral membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Brain and spinal cord. Highly enriched in axons.

亚基结构:

Interacts with SYTL4 (By similarity). Interacts with STX1A. Interacts with alpha-synuclein/SNCA; this interaction controls SNCA self-replicating aggregation. Interacts with RAB3A; this interaction promotes RAB3A dissociation from the vesicle membrane (By similarity). Interacts with CABP5 (By similarity).

蛋白家族:

Belongs to the STXBP/unc-18/SEC1 family.

研究领域

· Organismal Systems > Nervous system > Synaptic vesicle cycle.

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