Phospho-CD226/DNAM-1 (Ser329) Antibody - #AF4478
| 产品: | 磷酸化 CD226/DNAM-1 (Ser329) 抗体 |
| 货号: | AF4478 |
| 描述: | Rabbit polyclonal antibody to Phospho-CD226/DNAM-1 (Ser329) |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Monkey |
| 预测: | Pig, Horse |
| 分子量: | 58kDa; 39kD(Calculated). |
| 蛋白号: | Q15762 |
| RRID: | AB_2844641 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF4478, RRID:AB_2844641.
展开/折叠
adhesion glycoprotein; CD226; CD226 antigen; CD226 molecule; CD226_HUMAN; DNAM 1; DNAM-1; DNAM1; DNAX accessory molecule 1; platelet and T cell activation antigen 1; PTA1; T lineage specific activation antigen 1 antigen; TLiSA1;
抗原和靶标
- Q15762 CD226_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDYPTLLLALLHVYRALCEEVLWHTSVPFAENMSLECVYPSMGILTQVEWFKIGTQQDSIAIFSPTHGMVIRKPYAERVYFLNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQVVQSDSFEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNQYTLFVAGGTVLLLLFVISITTIIVIFLNRRRRRERRDLFTESWDTQKAPNNYRSPISTSQPTNQSMDDTREDIYVNYPTFSRRPKTRV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q15762 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K167 | Ubiquitination | Uniprot | |
| Y249 | Phosphorylation | Uniprot | |
| T250 | Phosphorylation | Uniprot | |
| S290 | Phosphorylation | Uniprot | |
| T293 | Phosphorylation | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| S313 | Phosphorylation | Uniprot | |
| Y322 | Phosphorylation | P06241 (FYN) | Uniprot |
| Y325 | Phosphorylation | Uniprot | |
| S329 | Phosphorylation | P17252 (PRKCA) | Uniprot |
研究背景
Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding.
Cell membrane>Single-pass type I membrane protein.
Expressed by peripheral blood T-lymphocytes.
Interacts with PVR and NECTIN2. Competes with PVRIG for NECTIN2-binding.
研究领域
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
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