| 产品: | 磷酸化 KIF1B (Ser1487) 抗体 |
| 货号: | AF2357 |
| 描述: | Rabbit polyclonal antibody to Phospho-KIF1B (Ser1487) |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 140, 200kDa; 204kD(Calculated). |
| 蛋白号: | O60333 |
| RRID: | AB_2845371 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF2357, RRID:AB_2845371.
展开/折叠
Charcot Marie Tooth neuropathy 2A; CMT 2; CMT 2A; CMT 2A1; CMT2 A; CMT2 A1; CMT2; CMT2A 1; CMT2A; CMT2A1; D4Mil1e; HMSN II; HMSNII; HMSNII, hereditary motor sensory neuropathy II; KIF 1B; KIF1 B; KIF1B p130; KIF1B p204; KIF1Bp130; KIF1Bp204; kinesin family member 1B; Kinesin like protein KIF1B; Klp;
抗原和靶标
Isoform 3 is abundant in the skeletal muscle. It is also expressed in fetal brain, lung and kidney, and adult heart, placenta, testis, ovary and small intestine. Isoform 2 is abundant in the brain and also expressed in fetal heart, lung, liver and kidney, and adult skeletal muscle, placenta, liver, kidney, heart, spleen, thymus, prostate, testis, ovary, small intestine, colon and pancreas.
- O60333 KIF1B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEAPKSFSFDYSYWSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLSTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRAQGLGDIIDIDPLIDDYSGSGSKYLKDFQNNKHRYLLASENQRPGHFSTASMGSLTSSPSSCSLSSQVGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERSNSGEVIVTLEPCERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQRELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKLQALQKQVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQFTSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPLPPELLPTEMEKTHEDRPFPRTVVAVEVQDLKNGATHYWSLEKLKQRLDLMREMYDRAGEMASSAQDESETTVTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQDEMEDFDDEAFVDDAGSDAGTEEGSDLFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEAPDYGSGIRQSGTAKISFDNEYFNQSDFSSVAMTRSGLSLEELRIVEGQGQSSEVITPPEEISRINDLDLKSSTLLDGKMVMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYADIFCQFNFLHRHDEAFSTEPLKNNGRGSPLAFYHVQNIAVEITESFVDYIKTKPIVFEVFGHYQQHPLHLQGQELNSPPQPCRRFFPPPMPLSKPVPATKLNTMSKTSLGQSMSKYDLLVWFEISELEPTGEYIPAVVDHTAGLPCQGTFLLHQGIQRRITVTIIHEKGSELHWKDVRELVVGRIRNKPEVDEAAVDAILSLNIISAKYLKSSHNSSRTFYRFEAVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPAVITKDVCMVFYSRDAKISPPRSLRSLFGSGYSKSPDSNRVTGIYELSLCKMSDTGSPGMQRRRRKILDTSVAYVRGEENLAGWRPRGDSLILEHQWELEKLELLHEVEKTRHFLLLRERLGDSIPKSLSDSLSPSLSSGTLSTSTSISSQISTTTFESAITPSESSGYDSGDIESLVDREKELATKCLQLLTHTFNREFSQVHGSVSDCKLSDISPIGRDPSESSFSSATLTPSSTCPSLVDSRSNSLDQKTPEANSRASSPCPEFEQFQIVPAVETPYLARAGKNEFLNLVPDIEEIRPSSVVSKKGYLHFKEPLYSNWAKHFVVVRRPYVFIYNSDKDPVERGIINLSTAQVEYSEDQQAMVKTPNTFAVCTKHRGVLLQALNDKDMNDWLYAFNPLLAGTIRSKLSRRCPSQSKY
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O60333 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| K7 | Acetylation | Uniprot | |
| R11 | Methylation | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| K266 | Ubiquitination | Uniprot | |
| S274 | Phosphorylation | Uniprot | |
| T276 | Phosphorylation | Uniprot | |
| T277 | Phosphorylation | Uniprot | |
| T301 | Phosphorylation | Uniprot | |
| K355 | Ubiquitination | Uniprot | |
| T467 | Phosphorylation | Uniprot | |
| T522 | Phosphorylation | Uniprot | |
| S527 | Phosphorylation | Uniprot | |
| K552 | Ubiquitination | Uniprot | |
| S572 | Phosphorylation | Uniprot | |
| C600 | S-Nitrosylation | Uniprot | |
| K646 | Ubiquitination | Uniprot | |
| T647 | Phosphorylation | Uniprot | |
| S654 | Phosphorylation | Uniprot | |
| K693 | Ubiquitination | Uniprot | |
| Y707 | Phosphorylation | Uniprot | |
| S709 | Phosphorylation | Uniprot | |
| K784 | Ubiquitination | Uniprot | |
| S892 | Phosphorylation | Uniprot | |
| S893 | Phosphorylation | Uniprot | |
| K999 | Ubiquitination | Uniprot | |
| S1035 | Phosphorylation | Uniprot | |
| Y1040 | Phosphorylation | Uniprot | |
| S1054 | Phosphorylation | Uniprot | |
| S1057 | Phosphorylation | Uniprot | |
| T1075 | Phosphorylation | Uniprot | |
| K1089 | Ubiquitination | Uniprot | |
| K1156 | Ubiquitination | Uniprot | |
| S1162 | Phosphorylation | Uniprot | |
| S1211 | Phosphorylation | Uniprot | |
| K1228 | Ubiquitination | Uniprot | |
| T1241 | Phosphorylation | Uniprot | |
| S1416 | Phosphorylation | Uniprot | |
| S1432 | Phosphorylation | Uniprot | |
| S1435 | Phosphorylation | Uniprot | |
| S1454 | Phosphorylation | Uniprot | |
| S1487 | Phosphorylation | Uniprot | |
| K1507 | Ubiquitination | Uniprot | |
| S1573 | Phosphorylation | Uniprot | |
| T1592 | Phosphorylation | Uniprot | |
| S1598 | Phosphorylation | Uniprot | |
| S1603 | Phosphorylation | Uniprot | |
| S1605 | Phosphorylation | Uniprot | |
| S1610 | Phosphorylation | Uniprot | |
| S1613 | Phosphorylation | Uniprot | |
| S1620 | Phosphorylation | Uniprot | |
| T1630 | Phosphorylation | Uniprot | |
| S1632 | Phosphorylation | Uniprot | |
| S1641 | Phosphorylation | Uniprot | |
| S1643 | Phosphorylation | Uniprot | |
| S1645 | Phosphorylation | Uniprot | |
| T1650 | Phosphorylation | Uniprot | |
| S1655 | Phosphorylation | Uniprot | |
| S1658 | Phosphorylation | Uniprot | |
| S1659 | Phosphorylation | Uniprot | |
| T1675 | Phosphorylation | Uniprot | |
| K1720 | Acetylation | Uniprot | |
| T1764 | Phosphorylation | Uniprot |
研究背景
Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis.
Isoform 1 mediates the transport of synaptic vesicles in neuronal cells.
Cytoplasm>Cytoskeleton. Mitochondrion.
Cytoplasmic vesicle>Secretory vesicle>Synaptic vesicle.
Isoform 3 is abundant in the skeletal muscle. It is also expressed in fetal brain, lung and kidney, and adult heart, placenta, testis, ovary and small intestine. Isoform 2 is abundant in the brain and also expressed in fetal heart, lung, liver and kidney, and adult skeletal muscle, placenta, liver, kidney, heart, spleen, thymus, prostate, testis, ovary, small intestine, colon and pancreas.
Monomer (By similarity). Interacts (via C-terminus end of the kinesin-motor domain) with CHP1; the interaction occurs in a calcium-dependent manner (By similarity). Interacts with KIFBP.
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.
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