产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF2413, RRID:AB_2845427.
展开/折叠
FLJ10928; FLJ20515; hSSH 3L; hSSH-3L; hSSH3L; Protein phosphatase Slingshot homolog 3; Slingshot 3; Slingshot homolog 3; Slingshot3; SSH 3; SSH 3L; SSH-3L; SSH-like protein 3; Ssh3; SSH3_HUMAN; SSH3L;
抗原和靶标
- Q8TE77 SSH3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALVTVSRSPPGSGASTPVGPWDQAVQRRSRLQRRQSFAVLRGAVLGLQDGGDNDDAAEASSEPTEKAPSEEELHGDQTDFGQGSQSPQKQEEQRQHLHLMVQLLRPQDDIRLAAQLEAPRPPRLRYLLVVSTREGEGLSQDETVLLGVDFPDSSSPSCTLGLVLPLWSDTQVYLDGDGGFSVTSGGQSRIFKPISIQTMWATLQVLHQACEAALGSGLVPGGSALTWASHYQERLNSEQSCLNEWTAMADLESLRPPSAEPGGSSEQEQMEQAIRAELWKVLDVSDLESVTSKEIRQALELRLGLPLQQYRDFIDNQMLLLVAQRDRASRIFPHLYLGSEWNAANLEELQRNRVTHILNMAREIDNFYPERFTYHNVRLWDEESAQLLPHWKETHRFIEAARAQGTHVLVHCKMGVSRSAATVLAYAMKQYECSLEQALRHVQELRPIARPNPGFLRQLQIYQGILTASRQSHVWEQKVGGVSPEEHPAPEVSTPFPPLPPEPEGGGEEKVVGMEESQAAPKEEPGPRPRINLRGVMRSISLLEPSLELESTSETSDMPEVFSSHESSHEEPLQPFPQLARTKGGQQVDRGPQPALKSRQSVVTLQGSAVVANRTQAFQEQEQGQGQGQGEPCISSTPRFRKVVRQASVHDSGEEGEA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q8TE77 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T5 | Phosphorylation | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| T17 | Phosphorylation | Uniprot | |
| S37 | Phosphorylation | Q96GD4 (AURKB) | Uniprot |
| K67 | Acetylation | Uniprot | |
| S70 | Phosphorylation | Uniprot | |
| T79 | Phosphorylation | Uniprot | |
| S85 | Phosphorylation | Uniprot | |
| S87 | Phosphorylation | Uniprot | |
| K90 | Ubiquitination | Uniprot | |
| S259 | Phosphorylation | Uniprot | |
| K281 | Ubiquitination | Uniprot | |
| S290 | Phosphorylation | Uniprot | |
| T292 | Phosphorylation | Uniprot | |
| S293 | Phosphorylation | Uniprot | |
| K294 | Ubiquitination | Uniprot | |
| S385 | Phosphorylation | Uniprot | |
| S484 | Phosphorylation | Uniprot | |
| K523 | Sumoylation | Uniprot | |
| S547 | Phosphorylation | Uniprot | |
| K598 | Methylation | Uniprot | |
| S602 | Phosphorylation | Uniprot | |
| T605 | Phosphorylation | Uniprot | |
| S609 | Phosphorylation | Uniprot | |
| S637 | Phosphorylation | Uniprot | |
| T638 | Phosphorylation | Uniprot | |
| S649 | Phosphorylation | Uniprot | |
| S653 | Phosphorylation | Uniprot |
研究背景
Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity).
Cytoplasm>Cytoskeleton. Nucleus.
Does not bind to, or colocalize with, filamentous actin.
Belongs to the protein-tyrosine phosphatase family.
研究领域
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Organismal Systems > Development > Axon guidance. (View pathway)
限制条款
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