Phospho-Dynamin 1 (Ser774) Antibody - #AF3396
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF3396, RRID:AB_2834827.
展开/折叠
B dynamin; D100; DNM 1; DNM; DNM1; DYN1_HUMAN; Dynamin; Dynamin-1; Dynamin1;
抗原和靶标
- Q05193 DYN1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQVKKIREPCLKCVDMVISELISTVRQCTKKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPARPGSRGPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAPPGVPSRSGQASPSRPESPRPPFDL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q05193 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S46 | Phosphorylation | Uniprot | |
| S61 | Phosphorylation | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| T214 | Phosphorylation | Uniprot | |
| R217 | Methylation | Uniprot | |
| K223 | Ubiquitination | Uniprot | |
| Y231 | Phosphorylation | P12931 (SRC) | Uniprot |
| K257 | Ubiquitination | Uniprot | |
| S261 | Phosphorylation | Uniprot | |
| S264 | Phosphorylation | Uniprot | |
| R271 | Methylation | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| S347 | Phosphorylation | Uniprot | |
| Y354 | Phosphorylation | Uniprot | |
| K376 | Ubiquitination | Uniprot | |
| T411 | Phosphorylation | Uniprot | |
| S433 | Phosphorylation | Uniprot | |
| S437 | Phosphorylation | Uniprot | |
| T438 | Phosphorylation | Uniprot | |
| T443 | Phosphorylation | Uniprot | |
| S512 | Phosphorylation | Uniprot | |
| K523 | Ubiquitination | Uniprot | |
| K598 | Acetylation | Uniprot | |
| S668 | Phosphorylation | Uniprot | |
| Y669 | Phosphorylation | Uniprot | |
| Y732 | Phosphorylation | Uniprot | |
| S774 | Phosphorylation | Uniprot | |
| T776 | Phosphorylation | Uniprot | |
| S777 | Phosphorylation | Uniprot | |
| S778 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| T780 | Phosphorylation | Q00535 (CDK5) | Uniprot |
| S795 | Phosphorylation | Q13627 (DYRK1A) | Uniprot |
| S822 | Phosphorylation | Uniprot | |
| S851 | Phosphorylation | Uniprot | |
| S857 | Phosphorylation | Q13627 (DYRK1A) | Uniprot |
研究背景
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
Cytoplasm. Cytoplasm>Cytoskeleton.
Note: Microtubule-associated.
Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3 (By similarity). Interacts with PHOCN. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Interacts with SNX9. Interacts with MYO1E (via SH3 domain). Interacts with SNX33 (via SH3 domain). Interacts with UNC119; leading to a decrease of DNM1 GTPase activity (By similarity). Interacts with DIAPH1. Interacts with AMPH, BIN1 AND SYNJ1 (By similarity).
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
研究领域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.
· Organismal Systems > Nervous system > Synaptic vesicle cycle.
· Organismal Systems > Excretory system > Endocrine and other factor-regulated calcium reabsorption.
限制条款
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