| 产品: | Prealbumin 抗体 |
| 货号: | BF0713 |
| 描述: | Mouse monoclonal antibody to Prealbumin |
| 应用: | WB IHC |
| 反应: | Human |
| 分子量: | 16 kDa; 16kD(Calculated). |
| 蛋白号: | P02766 |
| RRID: | AB_2846204 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# BF0713, RRID:AB_2846204.
展开/折叠
Amyloid;Amyloidosis I;ATTR;Carpal tunnel syndrome 1;CTS;Prealbumin;Transthyretin;Prealbumin;TTR
抗原和靶标
A synthetic peptide
Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.
- P02766 TTHY_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
翻译修饰 - P02766 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| C10 | S-Nitrosylation | Uniprot | |
| T23 | Phosphorylation | Uniprot | |
| T25 | Phosphorylation | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| N118 | N-Glycosylation | Uniprot | |
| Y125 | Phosphorylation | Uniprot | |
| S137 | Phosphorylation | Uniprot | |
| T138 | Phosphorylation | Uniprot |
研究背景
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYL-TTR 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway.
Secreted. Cytoplasm.
Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.
Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.
Each monomer has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel.
Belongs to the transthyretin family.
研究领域
· Organismal Systems > Endocrine system > Thyroid hormone synthesis.
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