| 产品: | 磷酸化 PIN4 (Tyr122) 抗体 |
| 货号: | AF3511 |
| 描述: | Rabbit polyclonal antibody to Phospho-PIN4 (Tyr122) |
| 应用: | IHC |
| 反应: | Human, Mouse, Rat |
| 分子量: | 14kD(Calculated). |
| 蛋白号: | Q9Y237 |
| RRID: | AB_2846825 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF3511, RRID:AB_2846825.
展开/折叠
EPVH; Eukaryotic parvulin homolog; hEPVH; hPar14; hPar17; MGC138486; OTTHUMP00000023527; OTTHUMP00000217483; OTTHUMP00000217485; Par14; Par17; Parvulin 14; Parvulin-14; Parvulin-17; Peptidyl prolyl cis trans isomerase NIMA interacting 4; Peptidyl prolyl cis/trans isomerase EPVH; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; Peptidyl-prolyl cis-trans isomerase PIN4; Peptidyl-prolyl cis/trans isomerase EPVH; PIN4; PIN4_HUMAN; PPIase Pin4; Protein (peptidylprolyl cis/trans isomerase) NIMA interacting, 4 (parvulin); Rotamase Pin4;
抗原和靶标
A synthesized peptide derived from human PIN4 around the phosphorylation site of Tyr122.
Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed.
- Q9Y237 PIN4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPPKGKSGSGKAGKGGAASGSDSADKKAQGPKGGGNAVKVRHILCEKHGKIMEAMEKLKSGMRFNEVAAQYSEDKARQGGDLGWMTRGSMVGPFQEAAFALPVSGMDKPVFTDPPVKTKFGYHIIMVEGRK
研究背景
Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA.
Isoform 2 binds to double-stranded DNA.
Phosphorylated. Isoform 1 phosphorylation occurs both in the nucleus and the cytoplasm. Isoform 1 phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated isoform 1 associates with the pre-rRNP complexes in the nucleus.
Isoform 2 is sumoylated with SUMO2 and SUMO3.
Nucleus>Nucleolus. Cytoplasm>Cytoskeleton>Spindle. Cytoplasm.
Note: Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1.
Mitochondrion. Mitochondrion matrix.
Note: Imported in a time- and membrane potential-dependent manner to the mitochondrial matrix, but without concomitant processing of the protein. Directed to mitochondria by a novel N-terminal domain that functions as non-cleavable mitochondrial targeting peptide.
Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed.
Isoform 1 is found in pre-ribosomal ribonucleoprotein (pre-rRNP) complexes.
The PPIase domain enhances mitochondrial targeting.
Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.
限制条款
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