| 产品: | 磷酸化 SIRT6 (Thr294) 抗体 |
| 货号: | AF3571 |
| 描述: | Rabbit polyclonal antibody to Phospho-SIRT6 (Thr294) |
| 应用: | IF/ICC |
| 反应: | Human |
| 分子量: | 39kD(Calculated). |
| 蛋白号: | Q8N6T7 |
| RRID: | AB_2846885 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF3571, RRID:AB_2846885.
展开/折叠
2810449N18Rik; AI043036; Mono ADP ribosyltransferase sirtuin 6; NAD-dependent protein deacetylase sirtuin-6; Regulatory protein SIR2 homolog 6; Regulatory protein SIR2 homolog; SIR2 like 6; SIR2 like protein 6; Sir2 related protein type 6; SIR2-like protein 6; SIR2L6; SIR6_HUMAN; SIRT 6; SIRT6; Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); Sirtuin 6; Sirtuin type 6; Sirtuin6;
抗原和靶标
A synthesized peptide derived from human SIRT6 around the phosphorylation site of Thr294.
- Q8N6T7 SIR6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
翻译修饰 - Q8N6T7 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| K17 | Ubiquitination | Uniprot | |
| K81 | Ubiquitination | Uniprot | |
| K128 | Ubiquitination | Uniprot | |
| T146 | Phosphorylation | Uniprot | |
| Y148 | Phosphorylation | Uniprot | |
| K160 | Ubiquitination | Uniprot | |
| T162 | Phosphorylation | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| K245 | Ubiquitination | Uniprot | |
| K267 | Ubiquitination | Uniprot | |
| T294 | Phosphorylation | Uniprot | |
| S303 | Phosphorylation | Uniprot | |
| T305 | Phosphorylation | Uniprot | |
| S310 | Phosphorylation | Uniprot | |
| S326 | Phosphorylation | Uniprot | |
| S330 | Phosphorylation | Uniprot | |
| T337 | Phosphorylation | Uniprot | |
| S338 | Phosphorylation | P31749 (AKT1) | Uniprot |
研究背景
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
Nucleus>Nucleoplasm.
Note: Predominantly nuclear. Associated with telomeric heterochromatin regions.
Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8.
Belongs to the sirtuin family. Class IV subfamily.
研究领域
· Human Diseases > Cancers: Overview > Central carbon metabolism in cancer. (View pathway)
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