| 产品: | 磷酸化 HRH1 (Ser398) 抗体 |
| 货号: | AF3678 |
| 描述: | Rabbit polyclonal antibody to Phospho-HRH1 (Ser398) |
| 应用: | IF/ICC |
| 反应: | Human, Mouse, Rat |
| 分子量: | 56kD(Calculated). |
| 蛋白号: | P35367 |
| RRID: | AB_2846992 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF3678, RRID:AB_2846992.
展开/折叠
BPHS, mouse, homolog of; H1 R; H1R; HH1R; HisH1; Histamine H(1) receptor; Histamine H1 receptor; Histamine receptor H1; Histamine receptor subclass H1; Hrh1; HRH1_HUMAN;
抗原和靶标
A synthesized peptide derived from human HRH1 around the phosphorylation site of Ser398.
- P35367 HRH1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
翻译修饰 - P35367 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S68 | Phosphorylation | Uniprot | |
| S70 | Phosphorylation | Uniprot | |
| T140 | Phosphorylation | Q9UQM7 (CAMK2A) | Uniprot |
| T142 | Phosphorylation | Q9UQM7 (CAMK2A) | Uniprot |
| S230 | Phosphorylation | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| K238 | Ubiquitination | Uniprot | |
| S255 | Phosphorylation | Uniprot | |
| K261 | Ubiquitination | Uniprot | |
| S271 | Phosphorylation | Uniprot | |
| S275 | Phosphorylation | Uniprot | |
| T279 | Phosphorylation | Uniprot | |
| K284 | Ubiquitination | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| Y301 | Phosphorylation | Uniprot | |
| Y321 | Phosphorylation | Uniprot | |
| S378 | Phosphorylation | Uniprot | |
| S380 | Phosphorylation | Uniprot | |
| Y386 | Phosphorylation | Uniprot | |
| S396 | Phosphorylation | Q9UQM7 (CAMK2A) , P17612 (PRKACA) , Q13976 (PRKG1) , P17252 (PRKCA) | Uniprot |
| S398 | Phosphorylation | Q13976 (PRKG1) , P17252 (PRKCA) , Q9UQM7 (CAMK2A) , P25098 (GRK2) , P17612 (PRKACA) | Uniprot |
| Y401 | Phosphorylation | Uniprot | |
| T478 | Phosphorylation | P17252 (PRKCA) | Uniprot |
研究背景
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor downregulation.
Cell membrane>Multi-pass membrane protein.
Belongs to the G-protein coupled receptor 1 family.
研究领域
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Organismal Systems > Sensory system > Inflammatory mediator regulation of TRP channels. (View pathway)
限制条款
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