| 产品: | 磷酸化 Kv1.3/KCNA3 (Ser520) 抗体 |
| 货号: | AF3702 |
| 描述: | Rabbit polyclonal antibody to Phospho-Kv1.3/KCNA3 (Ser520) |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 分子量: | 64kD(Calculated). |
| 蛋白号: | P22001 |
| RRID: | AB_2847016 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF3702, RRID:AB_2847016.
展开/折叠
HGK 5; HGK5; HLK 3; HLK3; HPCN 3; HPCN3; HuKIII; KCNA 3; Kcna3; KCNA3_HUMAN; KV1.3; MK 3; MK3; OTTHUMP00000032397; PCN 3; PCN3; Potassium channel 3; Potassium voltage gated channel shaker related subfamily member 3; Potassium voltage gated channel subfamily A member 3; Potassium voltage-gated channel subfamily A member 3; Type n potassium channel; Voltage gated potassium channel protein Kv1.3; Voltage gated potassium channel subunit Kv1.3; Voltage-gated K(+) channel HuKIII; Voltage-gated potassium channel subunit Kv1.3;
抗原和靶标
A synthesized peptide derived from human Kv1.3/KCNA3 around the phosphorylation site of Ser520.
- P22001 KCNA3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
翻译修饰 - P22001 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S10 | Phosphorylation | Uniprot | |
| K120 | Ubiquitination | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| Y161 | Phosphorylation | Q16620 (NTRK2) | Uniprot |
| Y162 | Phosphorylation | Q16620 (NTRK2) | Uniprot |
| Y163 | Phosphorylation | Q16620 (NTRK2) | Uniprot |
| Y187 | Phosphorylation | P12931 (SRC) | Uniprot |
| K196 | Ubiquitination | Uniprot | |
| S378 | Phosphorylation | Uniprot | |
| Y447 | Phosphorylation | P12931 (SRC) | Uniprot |
| Y499 | Phosphorylation | P12931 (SRC) , Q16620 (NTRK2) | Uniprot |
| S504 | Phosphorylation | Uniprot | |
| S511 | Phosphorylation | Uniprot | |
| S520 | Phosphorylation | Uniprot | |
| T523 | Phosphorylation | Uniprot | |
| S525 | Phosphorylation | Uniprot | |
| K526 | Ubiquitination | Uniprot | |
| S527 | Phosphorylation | Uniprot | |
| Y529 | Phosphorylation | Uniprot | |
| S564 | Phosphorylation | Uniprot | |
| K569 | Ubiquitination | Uniprot | |
| K570 | Ubiquitination | Uniprot |
研究背景
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
N-glycosylation promotes the cell surface expression.
Cell membrane>Multi-pass membrane protein.
Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity).
The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily.
限制条款
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