Phospho-Tryptophan Hydroxylase (Ser260) Antibody - #AF3713

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产品: 磷酸化 Tryptophan Hydroxylase (Ser260) 抗体
货号: AF3713
描述: Rabbit polyclonal antibody to Phospho-Tryptophan Hydroxylase (Ser260)
应用: IF/ICC
反应: Human, Mouse, Rat
分子量: 51kD(Calculated).
蛋白号: P17752
RRID: AB_2847027

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 100ul RMB¥ 2800 现货
 200ul RMB¥ 3800 现货

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实验方案
WB Handbook
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IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Polyclonal
特异性:
Phospho-Tryptophan Hydroxylase (Ser260) Antibody detects endogenous levels of Tryptophan Hydroxylase only when phosphorylated at Ser260.
RRID:
AB_2847027
引用格式: Affinity Biosciences Cat# AF3713, RRID:AB_2847027.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Indoleacetic acid 5 hydroxylase; L tryptophan hydroxylase; MGC119994; TPH 1; TPH; TPH1; TPH1_HUMAN; TPRH; TRPH; Tryptophan 5 hydroxylase 1; Tryptophan 5 monooxygenase 1; Tryptophan 5 monooxygenase; Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; Tryptophan hydroxylase 1;

抗原和靶标

免疫原:

A synthesized peptide derived from human Tryptophan Hydroxylase around the phosphorylation site of Ser260.

Uniprot:

P17752(TPH1_HUMAN) >>Visit HPA database.

基因/基因ID:
TPH1(7166)
表达:
P17752 TPH1_HUMAN:

Isoform 2 seems to be less widely expressed than isoform 1.

序列:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI

翻译修饰 - P17752 作为底物

Site PTM Type Enzyme
K33 Acetylation
S58 Phosphorylation
T225 Phosphorylation
S228 Phosphorylation
S260 Phosphorylation
Y373 Phosphorylation
Y401 Phosphorylation
Y404 Phosphorylation

研究背景

组织特异性:

Isoform 2 seems to be less widely expressed than isoform 1.

亚基结构:

Homotetramer.

蛋白家族:

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

研究领域

· Metabolism > Amino acid metabolism > Tryptophan metabolism.

· Metabolism > Metabolism of cofactors and vitamins > Folate biosynthesis.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Nervous system > Serotonergic synapse.

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