| 产品: | 磷酸化 SCD1 (Tyr55) 抗体 |
| 货号: | AF3781 |
| 描述: | Rabbit polyclonal antibody to Phospho-SCD1 (Tyr55) |
| 应用: | IF/ICC |
| 反应: | Human |
| 分子量: | 41 kDa; 42kD(Calculated). |
| 蛋白号: | O00767 |
| RRID: | AB_2847095 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF3781, RRID:AB_2847095.
展开/折叠
ACOD_HUMAN; Acyl-CoA desaturase; Delta(9)-desaturase; Delta-9 desaturase; Delta-9-Desaturase; FADS5; Fatty acid desaturase; PRO0998; SCD 1; SCD; SCD1; Stearoyl-CoA desaturase;
抗原和靶标
A synthesized peptide derived from human SCD1 around the phosphorylation site of Tyr55.
Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung.
- O00767 ACOD_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
翻译修饰 - O00767 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y14 | Phosphorylation | Uniprot | |
| K34 | Ubiquitination | Uniprot | |
| Y41 | Phosphorylation | Uniprot | |
| K51 | Sumoylation | Uniprot | |
| K51 | Ubiquitination | Uniprot | |
| Y55 | Phosphorylation | Uniprot | |
| Y59 | Phosphorylation | Uniprot | |
| K60 | Ubiquitination | Uniprot | |
| K62 | Ubiquitination | Uniprot | |
| K68 | Sumoylation | Uniprot | |
| K68 | Ubiquitination | Uniprot | |
| S80 | Phosphorylation | Uniprot | |
| T91 | Phosphorylation | Uniprot | |
| T95 | Phosphorylation | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| K196 | Ubiquitination | Uniprot | |
| S198 | Phosphorylation | Uniprot | |
| T199 | Phosphorylation | Uniprot | |
| S203 | Phosphorylation | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| K278 | Ubiquitination | Uniprot | |
| K338 | Ubiquitination | Uniprot | |
| K341 | Ubiquitination | Uniprot | |
| T351 | Phosphorylation | Uniprot | |
| K357 | Ubiquitination | Uniprot |
研究背景
Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).
Endoplasmic reticulum membrane>Multi-pass membrane protein.
Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung.
May self-associate and form homodimers.
The histidine box domains are involved in binding the catalytic metal ions.
Belongs to the fatty acid desaturase type 1 family.
研究领域
· Environmental Information Processing > Signal transduction > AMPK signaling pathway. (View pathway)
· Metabolism > Lipid metabolism > Biosynthesis of unsaturated fatty acids.
· Metabolism > Global and overview maps > Fatty acid metabolism.
· Organismal Systems > Endocrine system > PPAR signaling pathway.
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