| 产品: | 磷酸化 SNAP23 (Ser95) 抗体 |
| 货号: | AF3788 |
| 描述: | Rabbit polyclonal antibody to Phospho-SNAP23 (Ser95) |
| 应用: | ELISA(peptide) |
| 反应: | Human, Mouse, Rat |
| 分子量: | 23kD(Calculated). |
| 蛋白号: | O00161 |
| RRID: | AB_2847102 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF3788, RRID:AB_2847102.
展开/折叠
HsT17016; LS-B8340; SNAP 23; SNAP-23; SNAP23; SNAP23A; SNAP23B; SNP23_HUMAN; Synaptosomal associated protein 23; Synaptosomal associated protein 23kDa; Synaptosomal associated protein; Synaptosomal-associated protein 23; Vesicle membrane fusion protein SNAP 23; Vesicle membrane fusion protein SNAP23; Vesicle-membrane fusion protein SNAP-23;
抗原和靶标
A synthesized peptide derived from human SNAP23 around the phosphorylation site of Ser95.
- O00161 SNP23_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDNLSSEEIQQRAHQITDESLESTRRILGLAIESQDAGIKTITMLDEQKEQLNRIEEGLDQINKDMRETEKTLTELNKCCGLCVCPCNRTKNFESGKAYKTTWGDGGENSPCNVVSKQPGPVTNGQLQQPTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKDMALNIGNEIDAQNPQIKRITDKADTNRDRIDIANARAKKLIDS
翻译修饰 - O00161 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S5 | Phosphorylation | Uniprot | |
| S6 | Phosphorylation | Uniprot | |
| T17 | Phosphorylation | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| S23 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| T24 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| S34 | Phosphorylation | Uniprot | |
| K40 | Ubiquitination | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| K64 | Ubiquitination | Uniprot | |
| K71 | Ubiquitination | Uniprot | |
| T72 | Phosphorylation | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| S95 | Phosphorylation | P14618 (PKM) | Uniprot |
| K97 | Ubiquitination | Uniprot | |
| Y99 | Phosphorylation | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| T102 | Phosphorylation | Uniprot | |
| S110 | Phosphorylation | Uniprot | |
| C112 | S-Nitrosylation | Uniprot | |
| K117 | Ubiquitination | Uniprot | |
| S136 | Phosphorylation | Uniprot | |
| Y139 | Phosphorylation | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| T144 | Phosphorylation | Uniprot | |
| T157 | Phosphorylation | Uniprot | |
| S161 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| K185 | Ubiquitination | Uniprot | |
| K190 | Ubiquitination | Uniprot |
研究背景
Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.
Cell membrane>Peripheral membrane protein. Cell membrane>Lipid-anchor. Cell junction>Synapse>Synaptosome.
Note: Mainly localized to the plasma membrane.
Ubiquitous. Highest levels where found in placenta.
Homotetramer (via coiled-coil domain), also forms heterotetramers with STX4 and VAMP3. Found in a complex with VAMP8 and STX1A. Found in a complex with VAMP8 and STX4 in pancreas (By similarity). Interacts simultaneously with SNAPIN and SYN4 (By similarity). Interacts with STX1A (By similarity). Interacts with STX12 (By similarity). Interacts tightly to multiple syntaxins and synaptobrevins/VAMPs (By similarity). Interacts with ZDHHC13 (via ANK repeats) (By similarity). Interacts with ZDHHC17 (via ANK repeats).
Belongs to the SNAP-25 family.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > SNARE interactions in vesicular transport.
· Organismal Systems > Immune system > Platelet activation. (View pathway)
限制条款
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