产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF3840, RRID:AB_2847154.
展开/折叠
FLJ42816; HSPC082; KIAA0569; SIP 1; SIP1; Smad Interacting Protein 1; Smad-interacting protein 1; SMADIP 1; SMADIP1; ZEB 2; Zeb2; ZEB2_HUMAN; Zfhx1b; ZFHX1B protein; Zfx1b; Zinc finger E box binding protein 2; Zinc finger E-box-binding homeobox 2; Zinc finger homeobox 1b; zinc finger homeobox protein 1; Zinc finger homeobox protein 1b;
抗原和靶标
A synthesized peptide derived from human ZEB2 around the phosphorylation site of Ser784.
- O60315 ZEB2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKQPIMADGPRCKRRKQANPRRKNVVNYDNVVDTGSETDEEDKLHIAEDDGIANPLDQETSPASVPNHESSPHVSQALLPREEEEDEIREGGVEHPWHNNEILQASVDGPEEMKEDYDTMGPEATIQTAINNGTVKNANCTSDFEEYFAKRKLEERDGHAVSIEEYLQRSDTAIIYPEAPEELSRLGTPEANGQEENDLPPGTPDAFAQLLTCPYCDRGYKRLTSLKEHIKYRHEKNEENFSCPLCSYTFAYRTQLERHMVTHKPGTDQHQMLTQGAGNRKFKCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCIGLISVNGRMRNNIKTGSSPNSVSSSPTNSAITQLRNKLENGKPLSMSEQTGLLKIKTEPLDFNDYKVLMATHGFSGTSPFMNGGLGATSPLGVHPSAQSPMQHLGVGMEAPLLGFPTMNSNLSEVQKVLQIVDNTVSRQKMDCKAEEISKLKGYHMKDPCSQPEEQGVTSPNIPPVGLPVVSHNGATKSIIDYTLEKVNEAKACLQSLTTDSRRQISNIKKEKLRTLIDLVTDDKMIENHNISTPFSCQFCKESFPGPIPLHQHERYLCKMNEEIKAVLQPHENIVPNKAGVFVDNKALLLSSVLSEKGMTSPINPYKDHMSVLKAYYAMNMEPNSDELLKISIAVGLPQEFVKEWFEQRKVYQYSNSRSPSLERSSKPLAPNSNPPTKDSLLPRSPVKPMDSITSPSIAELHNSVTNCDPPLRLTKPSHFTNIKPVEKLDHSRSNTPSPLNLSSTSSKNSHSSSYTPNSFSSEELQAEPLDLSLPKQMKEPKSIIATKNKTKASSISLDHNSVSSSSENSDEPLNLTFIKKEFSNSNNLDNKSTNPVFSMNPFSAKPLYTALPPQSAFPPATFMPPVQTSIPGLRPYPGLDQMSFLPHMAYTYPTGAATFADMQQRRKYQRKQGFQGELLDGAQDYMSGLDDMTDSDSCLSRKKIKKTESGMYACDLCDKTFQKSSSLLRHKYEHTGKRPHQCQICKKAFKHKHHLIEHSRLHSGEKPYQCDKCGKRFSHSGSYSQHMNHRYSYCKREAEEREAAEREAREKGHLEPTELLMNRAYLQSITPQGYSDSEERESMPRDGESEKEHEKEGEDGYGKLGRQDGDEEFEEEEEESENKSMDTDPETIRDEEETGDHSMDDSSEDGKMETKSDHEEDNMEDGM
翻译修饰 - O60315 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R11 | Methylation | Uniprot | |
| T34 | Phosphorylation | Uniprot | |
| S36 | Phosphorylation | Uniprot | |
| T38 | Phosphorylation | Uniprot | |
| S64 | Phosphorylation | Uniprot | |
| T119 | Phosphorylation | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| Y147 | Phosphorylation | Uniprot | |
| S162 | Phosphorylation | Uniprot | |
| S184 | Phosphorylation | Uniprot | |
| T188 | Phosphorylation | Uniprot | |
| T254 | Phosphorylation | Uniprot | |
| T274 | Phosphorylation | Uniprot | |
| T285 | Phosphorylation | Uniprot | |
| S305 | Phosphorylation | Uniprot | |
| S324 | Phosphorylation | Uniprot | |
| S327 | Phosphorylation | Uniprot | |
| S330 | Phosphorylation | Uniprot | |
| S331 | Phosphorylation | Uniprot | |
| T350 | Phosphorylation | Uniprot | |
| S352 | Phosphorylation | Uniprot | |
| S353 | Phosphorylation | Uniprot | |
| S356 | Phosphorylation | Uniprot | |
| S358 | Phosphorylation | Uniprot | |
| S359 | Phosphorylation | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| T362 | Phosphorylation | Uniprot | |
| K377 | Acetylation | Uniprot | |
| K391 | Sumoylation | Uniprot | |
| S410 | Phosphorylation | Uniprot | |
| S431 | Phosphorylation | Uniprot | |
| T470 | Phosphorylation | Uniprot | |
| S505 | Phosphorylation | Uniprot | |
| K632 | Ubiquitination | Uniprot | |
| S641 | Phosphorylation | Uniprot | |
| S647 | Phosphorylation | Uniprot | |
| S703 | Phosphorylation | Uniprot | |
| S705 | Phosphorylation | Uniprot | |
| S707 | Phosphorylation | Uniprot | |
| S726 | Phosphorylation | Uniprot | |
| S731 | Phosphorylation | Uniprot | |
| S741 | Phosphorylation | Uniprot | |
| S778 | Phosphorylation | Uniprot | |
| S780 | Phosphorylation | Uniprot | |
| T782 | Phosphorylation | Uniprot | |
| S784 | Phosphorylation | Uniprot | |
| S796 | Phosphorylation | Uniprot | |
| T802 | Phosphorylation | Uniprot | |
| S805 | Phosphorylation | Uniprot | |
| S819 | Phosphorylation | Uniprot | |
| S829 | Phosphorylation | Uniprot | |
| T837 | Phosphorylation | Uniprot | |
| S840 | Phosphorylation | Uniprot | |
| S841 | Phosphorylation | Uniprot | |
| S843 | Phosphorylation | Uniprot | |
| S848 | Phosphorylation | Uniprot | |
| S853 | Phosphorylation | Uniprot | |
| K866 | Sumoylation | Uniprot | |
| S1050 | Phosphorylation | Uniprot | |
| S1115 | Phosphorylation | Uniprot | |
| T1117 | Phosphorylation | Uniprot | |
| S1122 | Phosphorylation | Uniprot | |
| S1124 | Phosphorylation | Uniprot | |
| S1129 | Phosphorylation | Uniprot | |
| S1136 | Phosphorylation | Uniprot | |
| S1167 | Phosphorylation | Uniprot | |
| T1185 | Phosphorylation | Uniprot | |
| S1189 | Phosphorylation | Uniprot | |
| S1193 | Phosphorylation | Uniprot | |
| S1194 | Phosphorylation | Uniprot | |
| S1203 | Phosphorylation | Uniprot |
研究背景
Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.
Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity.
Nucleus.
Binds activated SMAD1, activated SMAD2 and activated SMAD3; binding with SMAD4 is not detected (By similarity). Interacts with CBX4 and CTBP1.
Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
研究领域
· Human Diseases > Cancers: Overview > MicroRNAs in cancer.
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