| 产品: | 磷酸化 PYGL (Ser15) 抗体 |
| 货号: | AF3863 |
| 描述: | Rabbit polyclonal antibody to Phospho-PYGL (Ser15) |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat |
| 分子量: | 102kDa; 97kD(Calculated). |
| 蛋白号: | P06737 |
| RRID: | AB_2847177 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF3863, RRID:AB_2847177.
展开/折叠
Glycogen phosphorylase; Glycogen phosphorylase L; Glycogen phosphorylase liver; Glycogen phosphorylase liver form; GSD6; Hers disease, glycogen storage disease type VI; liver form; OTTHUMP00000233649; OTTHUMP00000233651; Phosphorylase glycogen liver; Pygl; PYGL_HUMAN;
抗原和靶标
- P06737 PYGL_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDIEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLPWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFPKDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEAYVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNESNKVNGN
翻译修饰 - P06737 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K3 | Ubiquitination | Uniprot | |
| T6 | Phosphorylation | Uniprot | |
| K10 | Ubiquitination | Uniprot | |
| S15 | Phosphorylation | Uniprot | |
| K29 | Acetylation | Uniprot | |
| K29 | Ubiquitination | Uniprot | |
| K30 | Ubiquitination | Uniprot | |
| S31 | Phosphorylation | Uniprot | |
| T39 | Phosphorylation | Uniprot | |
| K42 | Ubiquitination | Uniprot | |
| Y75 | Phosphorylation | Uniprot | |
| Y76 | Phosphorylation | Uniprot | |
| R82 | Methylation | Uniprot | |
| Y85 | Phosphorylation | Uniprot | |
| Y114 | Phosphorylation | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| Y186 | Phosphorylation | Uniprot | |
| K192 | Ubiquitination | Uniprot | |
| S193 | Phosphorylation | Uniprot | |
| Y204 | Phosphorylation | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| R248 | Methylation | Uniprot | |
| Y263 | Phosphorylation | Uniprot | |
| Y281 | Phosphorylation | Uniprot | |
| K290 | Ubiquitination | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| K316 | Ubiquitination | Uniprot | |
| K359 | Ubiquitination | Uniprot | |
| S363 | Phosphorylation | Uniprot | |
| K364 | Ubiquitination | Uniprot | |
| K371 | Ubiquitination | Uniprot | |
| K395 | Ubiquitination | Uniprot | |
| Y405 | Phosphorylation | Uniprot | |
| K410 | Ubiquitination | Uniprot | |
| R414 | Methylation | Uniprot | |
| K421 | Ubiquitination | Uniprot | |
| S430 | Phosphorylation | Uniprot | |
| K438 | Ubiquitination | Uniprot | |
| S450 | Phosphorylation | Uniprot | |
| K465 | Ubiquitination | Uniprot | |
| K470 | Acetylation | Uniprot | |
| K470 | Ubiquitination | Uniprot | |
| S473 | Phosphorylation | Uniprot | |
| K479 | Ubiquitination | Uniprot | |
| K483 | Ubiquitination | Uniprot | |
| K514 | Ubiquitination | Uniprot | |
| S517 | Phosphorylation | Uniprot | |
| K521 | Ubiquitination | Uniprot | |
| S524 | Phosphorylation | Uniprot | |
| K545 | Ubiquitination | Uniprot | |
| S547 | Phosphorylation | Uniprot | |
| K555 | Ubiquitination | Uniprot | |
| K557 | Ubiquitination | Uniprot | |
| K569 | Ubiquitination | Uniprot | |
| K575 | Acetylation | Uniprot | |
| K609 | Ubiquitination | Uniprot | |
| S626 | Phosphorylation | Uniprot | |
| S639 | Phosphorylation | Uniprot | |
| K640 | Ubiquitination | Uniprot | |
| K642 | Ubiquitination | Uniprot | |
| K656 | Ubiquitination | Uniprot | |
| K724 | Acetylation | Uniprot | |
| K724 | Ubiquitination | Uniprot | |
| K725 | Ubiquitination | Uniprot | |
| K730 | Ubiquitination | Uniprot | |
| S752 | Phosphorylation | Uniprot | |
| K754 | Ubiquitination | Uniprot | |
| Y778 | Phosphorylation | Uniprot | |
| K783 | Ubiquitination | Uniprot | |
| K787 | Ubiquitination | Uniprot | |
| K796 | Ubiquitination | Uniprot | |
| K804 | Ubiquitination | Uniprot | |
| K811 | Ubiquitination | Uniprot | |
| R816 | Methylation | Uniprot | |
| K819 | Ubiquitination | Uniprot | |
| K834 | Acetylation | Uniprot | |
| K834 | Ubiquitination | Uniprot | |
| S836 | Phosphorylation | Uniprot | |
| S838 | Phosphorylation | Uniprot | |
| K843 | Ubiquitination | Uniprot |
研究背景
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.
Homodimer. Dimers associate into a tetramer to form the enzymatically active phosphorylase A. Interacts with PPP1R3B (By similarity).
Belongs to the glycogen phosphorylase family.
研究领域
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.
· Metabolism > Carbohydrate metabolism > Starch and sucrose metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Endocrine system > Insulin signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Glucagon signaling pathway.
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