| 产品: | 磷酸化 MLKL (Ser347) 抗体 |
| 货号: | AF3903 |
| 描述: | Rabbit polyclonal antibody to Phospho-MLKL (Ser347) |
| 应用: | IHC IF/ICC |
| 反应: | Human, Mouse |
| 分子量: | 36kD(Calculated). |
| 蛋白号: | Q9D2Y5 |
| RRID: | AB_2847217 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF3903, RRID:AB_2847217.
抗原和靶标
A synthesized peptide derived from mouse MLKL around the phosphorylation site of Ser347.
- Q9D2Y5 SNX20_MOUSE:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASPEHPGSPGWRGPINQCRTRTRQEVLPPGPDLPCPGPEEAQDGPSSNSSMTTRELQEHWQKEKSRWKHVRLLFEIASARIEERKVSKFVMYQVVVIQTGSFDSDKAVVERRYSDFERLQKALLKRFGPELEDVTFPRKRLTGNLSAETICERRRELREYLRLLYAVRAVRRSREFLDFLTRPELREAFGCLRAGQYARALELLGRALPLQEKLTAHCPSAAVPALCAALVCLRDLERPAEAFAVGERALRCLRTRENHRYYAPLLDAMVRLAYALGKDFAALQSRLDENQLRRPTHRDATLKELTVREYLS
研究背景
May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, nor on SELPLG-mediated cell-cell adhesion.
Early endosome membrane>Peripheral membrane protein>Cytoplasmic side. Cell membrane. Cytoplasm. Nucleus.
Interacts with SELPLG (By similarity). Interaction with SELPLG is controversial and was not detected in.
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for localization to the endosomes.
Belongs to the sorting nexin family.
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