| 产品: | 磷酸化 CRMP2 (Thr509) 抗体 |
| 货号: | AF3919 |
| 描述: | Rabbit polyclonal antibody to Phospho-CRMP2 (Thr509) |
| 应用: | WB ELISA(peptide) |
| 反应: | Human, Rat |
| 分子量: | 62kD(Calculated). |
| 蛋白号: | Q16555 |
| RRID: | AB_2847642 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF3919, RRID:AB_2847642.
展开/折叠
Collapsin response mediator protein 2; Collapsin response mediator protein; Collapsin response mediator protein hCRMP 2; CRAM; CRMP 2; CRMP-2; CRMP2; DHPRP 2; DHPRP2; Dihydropyrimidinase 2; Dihydropyrimidinase like 2; Dihydropyrimidinase like 2 long form; Dihydropyrimidinase related protein 2; Dihydropyrimidinase-related protein 2; DPYL 2; DPYL2; DPYL2_HUMAN; DPYSL 2; Dpysl2; DRP-2; DRP2; Musunc 33; Musunc33; N2A3; TOAD 64; TOAD64; ULIP 2 protein; ULIP-2; Ulip2; Unc-33-like phosphoprotein 2;
抗原和靶标
A synthesized peptide derived from human CRMP2 around the phosphorylation site of Thr509.
- Q16555 DPYL2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLHVDISEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIANQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRIAVGSDADLVIWDPDSVKTISAKTHNSSLEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFSLSGAQIDDNIPRRTTQRIVAPPGGRANITSLG
翻译修饰 - Q16555 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Phosphorylation | Uniprot | ||
| S2 | Phosphorylation | Uniprot | |
| T13 | Phosphorylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| Y32 | Phosphorylation | P06241 (FYN) | Uniprot |
| T57 | Phosphorylation | Uniprot | |
| T74 | Phosphorylation | Uniprot | |
| S85 | Phosphorylation | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| K258 | Ubiquitination | Uniprot | |
| K270 | Ubiquitination | Uniprot | |
| T280 | Phosphorylation | Uniprot | |
| K293 | Ubiquitination | Uniprot | |
| S304 | Phosphorylation | Uniprot | |
| S308 | Phosphorylation | Uniprot | |
| K345 | Acetylation | Uniprot | |
| K345 | Ubiquitination | Uniprot | |
| T358 | Phosphorylation | Uniprot | |
| K368 | Ubiquitination | Uniprot | |
| K374 | Ubiquitination | Uniprot | |
| K390 | Ubiquitination | Uniprot | |
| S416 | Phosphorylation | Uniprot | |
| K418 | Ubiquitination | Uniprot | |
| K423 | Ubiquitination | Uniprot | |
| T424 | Phosphorylation | Uniprot | |
| Y431 | Phosphorylation | Uniprot | |
| C439 | S-Nitrosylation | Uniprot | |
| K472 | Ubiquitination | Uniprot | |
| Y479 | Phosphorylation | P07947 (YES1) | Uniprot |
| R492 | Methylation | Uniprot | |
| Y499 | Phosphorylation | Uniprot | |
| C504 | S-Nitrosylation | Uniprot | |
| S507 | Phosphorylation | Uniprot | |
| T509 | Phosphorylation | P49841 (GSK3B) | Uniprot |
| K511 | Ubiquitination | Uniprot | |
| T512 | Phosphorylation | Uniprot | |
| T514 | Phosphorylation | P49841 (GSK3B) | Uniprot |
| S517 | Phosphorylation | Uniprot | |
| S518 | Phosphorylation | P49840 (GSK3A) , P49841 (GSK3B) | Uniprot |
| K520 | Acetylation | Uniprot | |
| K520 | Ubiquitination | Uniprot | |
| T521 | Phosphorylation | Uniprot | |
| S522 | Phosphorylation | Q92630 (DYRK2) , Q00535 (CDK5) | Uniprot |
| K525 | Acetylation | Uniprot | |
| K525 | Ubiquitination | Uniprot | |
| S537 | Phosphorylation | Uniprot | |
| S540 | Phosphorylation | Uniprot | |
| S542 | Phosphorylation | Uniprot | |
| T554 | Phosphorylation | Uniprot | |
| T555 | Phosphorylation | Q13464 (ROCK1) , O75116 (ROCK2) | Uniprot |
| R565 | Methylation | Uniprot | |
| T569 | Phosphorylation | Uniprot | |
| S570 | Phosphorylation | Uniprot |
研究背景
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509.
Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B.
Cytoplasm>Cytosol. Cytoplasm>Cytoskeleton. Membrane.
Note: Tightly but non-covalently associated with membranes.
Ubiquitous.
Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.
Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
研究领域
· Organismal Systems > Development > Axon guidance. (View pathway)
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