| 产品: | 磷酸化 FADD (Ser190) 抗体 |
| 货号: | AF3930 |
| 描述: | Rabbit polyclonal antibody to Phospho-FADD (Ser190) |
| 应用: | WB ELISA(peptide) |
| 反应: | Human, Mouse |
| 分子量: | 23kD(Calculated). |
| 蛋白号: | Q13158 |
| RRID: | AB_2847653 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF3930, RRID:AB_2847653.
展开/折叠
FADD; FADD protein; FADD_HUMAN; Fas (TNFRSF6) associated via death domain; Fas associated via death domain; Fas associating death domain containing protein; Fas associating protein; Fas associating protein with death domain; Fas TNFRSF6 associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; GIG 3; GIG3; Growth inhibiting gene 3 protein; Growth-inhibiting gene 3 protein; H sapiens mRNA for mediator of receptor induced toxicity; Mediator of receptor induced toxicity; MGC8528; MORT 1; MORT1; Protein FADD;
抗原和靶标
A synthesized peptide derived from human FADD around the phosphorylation site of Ser190.
Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
- Q13158 FADD_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDPFLVLLHSVSSSLSSSELTELKFLCLGRVGKRKLERVQSGLDLFSMLLEQNDLEPGHTELLRELLASLRRHDLLRRVDDFEAGAAAGAAPGEEDLCAAFNVICDNVGKDWRRLARQLKVSDTKIDSIEDRYPRNLTERVRESLRIWKNTEKENATVAHLVGALRSCQMNLVADLVQEVQQARDLQNRSGAMSPMSWNSDASTSEAS
翻译修饰 - Q13158 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S16 | Phosphorylation | Uniprot | |
| S18 | Phosphorylation | Uniprot | |
| T21 | Phosphorylation | Uniprot | |
| S41 | Phosphorylation | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| K120 | Sumoylation | Uniprot | |
| K125 | Sumoylation | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| R132 | Methylation | Uniprot | |
| Y133 | Phosphorylation | Uniprot | |
| T138 | Phosphorylation | Uniprot | |
| K149 | Sumoylation | Uniprot | |
| K149 | Ubiquitination | Uniprot | |
| K153 | Ubiquitination | Uniprot | |
| T157 | Phosphorylation | Uniprot | |
| R166 | Methylation | Uniprot | |
| S167 | Phosphorylation | Uniprot | |
| S190 | Phosphorylation | Uniprot | |
| S194 | Phosphorylation | P53350 (PLK1) , O14733 (MAP2K7) , Q9BV47 (DUSP26) , Q9H422 (HIPK3) , P48729 (CSNK1A1) , Q13233 (MAP3K1) | Uniprot |
| S197 | Phosphorylation | Uniprot | |
| S200 | Phosphorylation | P67870 (CSNK2B) | Uniprot |
| S203 | Phosphorylation | O14965 (AURKA) | Uniprot |
研究背景
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
Can self-associate. Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and PIDD1. Interacts (via death domain) with FAS (via death domain). Interacts with CASP8. Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (By similarity). Interacts with RIPK1, TRADD and CASP8 (By similarity). Interacts with stimulated TNFRSF10B.
(Microbial infection) Interacts with human papillomavirus 16/HPV16 protein E6.
(Microbial infection) Interacts with molluscum contagiosum virus proteins MC159L/v-CFLAR and MC160L.
Contains a death domain involved in the binding of the corresponding domain within Fas receptor.
The interaction between the FAS and FADD death domains is crucial for the formation of the death-inducing signaling complex (DISC).
研究领域
· Cellular Processes > Cell growth and death > Apoptosis. (View pathway)
· Cellular Processes > Cell growth and death > Apoptosis - multiple species. (View pathway)
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Environmental Information Processing > Signal transduction > TNF signaling pathway. (View pathway)
· Human Diseases > Drug resistance: Antineoplastic > Platinum drug resistance.
· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.
· Human Diseases > Infectious diseases: Parasitic > Chagas disease (American trypanosomiasis).
· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.
· Human Diseases > Infectious diseases: Viral > Hepatitis B.
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Organismal Systems > Immune system > Toll-like receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > RIG-I-like receptor signaling pathway. (View pathway)
· Organismal Systems > Immune system > IL-17 signaling pathway. (View pathway)
限制条款
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