| 产品: | 磷酸化 PEA15 (Ser104) 抗体 |
| 货号: | AF3963 |
| 描述: | Rabbit polyclonal antibody to Phospho-PEA15 (Ser104) |
| 应用: | IHC |
| 反应: | Human, Mouse, Rat |
| 分子量: | 15kD(Calculated). |
| 蛋白号: | Q15121 |
| RRID: | AB_2847686 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF3963, RRID:AB_2847686.
展开/折叠
15 kDa phosphoprotein enriched in astrocytes; Astrocytic phosphoprotein PEA 15; Astrocytic phosphoprotein PEA-15; Astrocytic phosphoprotein PEA15; HMAT 1; HMAT1; Homolog of mouse MAT 1 oncogene; Homolog of mouse MAT1 oncogene; HUMMAT 1H; HUMMAT1H; MAT 1; MAT 1H; MAT1; MAT1H; PEA 15; Pea15; PEA15 protein; PEA15_HUMAN; PED; Phosphoprotein enriched in astrocytes 15; Phosphoprotein enriched in astrocytes 15kD; Phosphoprotein enriched in diabetes;
抗原和靶标
A synthesized peptide derived from human PEA15 around the phosphorylation site of Ser104.
Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.
- Q15121 PEA15_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAEYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKSEEITTGSAWFSFLESHNKLDKDNLSYIEHIFEISRRPDLLTMVVDYRTRVLKISEEDELDTKLTRIPSAKKYKDIIRQPSEEEIIKLAPPPKKA
翻译修饰 - Q15121 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y4 | Phosphorylation | Uniprot | |
| T6 | Phosphorylation | Uniprot | |
| K24 | Ubiquitination | Uniprot | |
| S25 | Phosphorylation | Uniprot | |
| C27 | S-Nitrosylation | Uniprot | |
| K28 | Ubiquitination | Uniprot | |
| S43 | Phosphorylation | Uniprot | |
| K54 | Ubiquitination | Uniprot | |
| S61 | Phosphorylation | Uniprot | |
| S90 | Phosphorylation | Uniprot | |
| T97 | Phosphorylation | Uniprot | |
| K98 | Ubiquitination | Uniprot | |
| T100 | Phosphorylation | Uniprot | |
| S104 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| Y108 | Phosphorylation | Uniprot | |
| K109 | Methylation | Uniprot | |
| S116 | Phosphorylation | P31749 (AKT1) , Q9UQM7 (CAMK2A) , P54646 (PRKAA2) | Uniprot |
研究背景
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones.
Cytoplasm.
Note: Associated with microtubules.
Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.
Binds RPS6KA3, MAPK3 and MAPK1. Transient interaction with PLD1 and PLD2 (By similarity). Interacts with CASP8 and FADD.
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