| 产品: | 磷酸化 APLP2 (Tyr755) 抗体 |
| 货号: | AF3971 |
| 描述: | Rabbit polyclonal antibody to Phospho-APLP2 (Tyr755) |
| 应用: | IHC |
| 反应: | Human, Mouse, Rat |
| 分子量: | 87kD(Calculated). |
| 蛋白号: | Q06481 |
| RRID: | AB_2847694 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF3971, RRID:AB_2847694.
展开/折叠
amyloid beta (A4) precursor like protein 2; Amyloid like protein 2; Amyloid precursor protein homolog HSD 2; amyloid precursor protein homolog HSD2; Amyloid protein homolog; Amyloid-like protein 2; APLP-2; Aplp2; APLP2_HUMAN; APPH; APPL2; CDEBP; CDEI box binding protein; CDEI box-binding protein;
抗原和靶标
A synthesized peptide derived from human APLP2 around the phosphorylation site of Tyr755.
Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.
- Q06481 APLP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
翻译修饰 - Q06481 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K78 | Ubiquitination | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| S213 | Phosphorylation | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| Y233 | Phosphorylation | Uniprot | |
| T303 | Phosphorylation | Uniprot | |
| Y327 | Phosphorylation | Uniprot | |
| T367 | O-Glycosylation | Uniprot | |
| T371 | O-Glycosylation | Uniprot | |
| T380 | O-Glycosylation | Uniprot | |
| S381 | O-Glycosylation | Uniprot | |
| K420 | Ubiquitination | Uniprot | |
| R467 | Methylation | Uniprot | |
| S590 | Phosphorylation | Uniprot | |
| T658 | O-Glycosylation | Uniprot | |
| T723 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| T736 | Phosphorylation | P53779 (MAPK10) , P45983 (MAPK8) , P06493 (CDK1) , P45984 (MAPK9) | Uniprot |
| K744 | Ubiquitination | Uniprot | |
| Y750 | Phosphorylation | Uniprot | |
| T754 | Phosphorylation | Uniprot | |
| Y755 | Phosphorylation | Uniprot | |
| K756 | Ubiquitination | Uniprot | |
| Y757 | Phosphorylation | Uniprot |
研究背景
May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity).
The BPTI/Kunitz inhibitor domain is O-glycosylated.
Cell membrane>Single-pass type I membrane protein. Nucleus.
Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.
Interacts with CPEB1. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (By similarity).
Belongs to the APP family.
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