AFfirm™ ALDOA Mouse Monoclonal Antibody - #BF8051

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产品: ALDOA 小鼠 单克隆 抗体
货号: BF8051
描述: Mouse monoclonal antibody to ALDOA
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
分子量: 39 KD; 39kD(Calculated).
蛋白号: P04075

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   规格 价格 库存
 100ul RMB¥ 688 2300 现货

货期: 当天发货

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MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Mouse
应用:
WB 1:1000-1:10000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Monoclonal [AFfirm8051]
特异性:
ALDOA Antibody detects endogenous levels of total ALDOA.
偶联:
Unconjugated.
纯化:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

ALDA; Aldo1; ALDOA; ALDOA_HUMAN; Aldolase 1; Aldolase A; Aldolase A fructose bisphosphatase; Aldolase A fructose bisphosphate; Aldolase, fructose-bisphosphate A; Epididymis secretory sperm binding protein Li 87p; FRUCTOALDOLASE A; Fructose 1 6 bisphosphate triosephosphate lyase; Fructose bisphosphate aldolase A; Fructose bisphosphate aldolase; FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE A; Fructose-bisphosphate aldolase A; Fructose-bisphosphate aldolase A Muscle-type; GSD12; HEL S 87p; Lung cancer antigen NY LU 1; Lung cancer antigen NY-LU-1; MGC10942; MGC17716; MGC17767; Muscle type aldolase; Muscle-type aldolase; RNALDOG5;

抗原和靶标

免疫原:

A synthesized peptide derived from human ALDOA, corresponding to a region within N-terminal amino acids.

Uniprot:

P04075(ALDOA_HUMAN) >>Visit HPA database.

基因/基因ID:
ALDOA(226)
序列:
MPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKFSHEEIAMATVTALRRTVPPAVTGITFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSGQAGAAASESLFVSNHAY

翻译修饰 - P04075 作为底物

Site PTM Type Enzyme
Y3 Phosphorylation
Y5 Phosphorylation
T9 Phosphorylation
K13 Acetylation
K13 Ubiquitination
K14 Acetylation
K14 Ubiquitination
S17 Phosphorylation
K28 Ubiquitination
S36 Phosphorylation
T37 Phosphorylation
S39 Phosphorylation
K42 Acetylation
K42 Sumoylation
K42 Ubiquitination
S46 Phosphorylation
T49 Phosphorylation
T52 Phosphorylation
R56 Methylation
T65 Phosphorylation
R69 Methylation
C73 S-Nitrosylation
K87 Ubiquitination
K99 Methylation
K99 Ubiquitination
S100 Phosphorylation
K101 Methylation
K101 Ubiquitination
K108 Acetylation
K108 Sumoylation
K108 Ubiquitination
K111 Acetylation
K111 Ubiquitination
S132 Phosphorylation
R134 Methylation
Y138 Phosphorylation
K139 Acetylation
K139 Ubiquitination
K140 Ubiquitination
K147 Acetylation
K147 Ubiquitination
K153 Acetylation
K153 Ubiquitination
T158 Phosphorylation
S160 Phosphorylation
Y174 Phosphorylation
S176 Phosphorylation
K200 Acetylation
K200 Ubiquitination
Y204 Phosphorylation
T206 Phosphorylation
K208 Acetylation
K208 Ubiquitination
Y214 Phosphorylation
K215 Methylation
K215 Ubiquitination
S218 Phosphorylation
Y223 Phosphorylation
T227 Phosphorylation
K230 Acetylation
K230 Ubiquitination
T235 Phosphorylation
C240 S-Nitrosylation
T241 Phosphorylation
T269 Phosphorylation
S272 Phosphorylation
S276 Phosphorylation
K294 Acetylation
K294 Methylation
K294 Ubiquitination
T299 Phosphorylation
S301 Phosphorylation
S309 Phosphorylation
K312 Acetylation
K312 Methylation
K312 Ubiquitination
K318 Ubiquitination
K322 Acetylation
K322 Methylation
K322 Ubiquitination
Y328 Phosphorylation
K330 Acetylation
K330 Ubiquitination
S336 Phosphorylation
C339 S-Nitrosylation
K342 Acetylation
K342 Ubiquitination
Y343 Phosphorylation
T344 Phosphorylation
S346 Phosphorylation
S354 Phosphorylation
S356 Phosphorylation
S360 Phosphorylation
Y364 Phosphorylation

研究背景

功能:

Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).

细胞定位:

Cytoplasm>Myofibril>Sarcomere>I band. Cytoplasm>Myofibril>Sarcomere>M line.
Note: In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Homotetramer. Interacts with SNX9 and WAS (By similarity). Interacts with FBP2; the interaction blocks FBP2 inhibition by physiological concentrations of AMP and reduces inhibition by Ca(2+).

蛋白家族:

Belongs to the class I fructose-bisphosphate aldolase family.

研究领域

· Environmental Information Processing > Signal transduction > HIF-1 signaling pathway.   (View pathway)

· Metabolism > Carbohydrate metabolism > Glycolysis / Gluconeogenesis.

· Metabolism > Carbohydrate metabolism > Pentose phosphate pathway.

· Metabolism > Carbohydrate metabolism > Fructose and mannose metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

· Metabolism > Global and overview maps > Carbon metabolism.

· Metabolism > Global and overview maps > Biosynthesis of amino acids.

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