产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
展开/折叠
HNRNPA 1; Helix destabilizing protein; Helix-destabilizing protein; Heterogeneous nuclear ribonucleoprotein A1; Heterogeneous nuclear ribonucleoprotein A1B protein; Heterogeneous nuclear ribonucleoprotein B2 protein; Heterogeneous nuclear ribonucleoprotein core protein A1; hnRNP A1; hnRNP core protein A1; HNRNPA1; HNRPA1; MGC102835; Nuclear ribonucleoprotein particle A1 protein; ROA1_HUMAN; Single strand DNA binding protein UP1; Single strand RNA binding protein; Single-strand RNA-binding protein;
抗原和靶标
A synthesized peptide derived from human hnRNP A1, corresponding to a region within the internal amino acids.
- P09651 ROA1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF
翻译修饰 - P09651 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | Uniprot | |
| K3 | Acetylation | Uniprot | |
| K3 | Ubiquitination | Uniprot | |
| S4 | Phosphorylation | Q9UBS0 (RPS6KB2) | Uniprot |
| S6 | Phosphorylation | Q9UBS0 (RPS6KB2) | Uniprot |
| K8 | Acetylation | Uniprot | |
| K8 | Ubiquitination | Uniprot | |
| R14 | Methylation | Uniprot | |
| K15 | Acetylation | Uniprot | |
| K15 | Sumoylation | Uniprot | |
| K15 | Ubiquitination | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| T25 | Phosphorylation | Uniprot | |
| S29 | Phosphorylation | Uniprot | |
| R31 | Methylation | Uniprot | |
| C43 | S-Nitrosylation | Uniprot | |
| K52 | Acetylation | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| R55 | Methylation | Uniprot | |
| T61 | Phosphorylation | Uniprot | |
| Y62 | Phosphorylation | Uniprot | |
| K78 | Ubiquitination | Uniprot | |
| K87 | Acetylation | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| S91 | Phosphorylation | Uniprot | |
| S95 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| T103 | Phosphorylation | Uniprot | |
| K105 | Acetylation | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| K106 | Methylation | Uniprot | |
| K106 | Ubiquitination | Uniprot | |
| K113 | Acetylation | Uniprot | |
| K113 | Sumoylation | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| R122 | Methylation | Uniprot | |
| Y124 | Phosphorylation | Uniprot | |
| Y128 | Phosphorylation | Uniprot | |
| T138 | Phosphorylation | Uniprot | |
| R140 | Methylation | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| K144 | Acetylation | Uniprot | |
| K144 | Ubiquitination | Uniprot | |
| K145 | Acetylation | Uniprot | |
| R146 | Methylation | Uniprot | |
| S158 | Phosphorylation | Uniprot | |
| K161 | Methylation | Uniprot | |
| K161 | Ubiquitination | Uniprot | |
| K166 | Acetylation | Uniprot | |
| K166 | Ubiquitination | Uniprot | |
| Y167 | Phosphorylation | Uniprot | |
| T169 | Phosphorylation | Uniprot | |
| C175 | S-Nitrosylation | Uniprot | |
| K183 | Sumoylation | Uniprot | |
| K183 | Ubiquitination | Uniprot | |
| S190 | Phosphorylation | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| S192 | Phosphorylation | Q9BUB5 (MKNK1) | Uniprot |
| R194 | Methylation | Uniprot | |
| R196 | Methylation | Uniprot | |
| S197 | Phosphorylation | Uniprot | |
| S199 | Phosphorylation | P17612 (PRKACA) , P68400 (CSNK2A1) , P31749 (AKT1) | Uniprot |
| R206 | Methylation | Uniprot | |
| R218 | Methylation | Uniprot | |
| R225 | Methylation | Uniprot | |
| R232 | Methylation | Uniprot | |
| Y244 | Phosphorylation | Uniprot | |
| Y253 | Phosphorylation | Uniprot | |
| R265 | Methylation | Uniprot | |
| Y312 | Phosphorylation | Uniprot | |
| Y318 | Phosphorylation | Uniprot | |
| K329 | Sumoylation | Uniprot | |
| R336 | Methylation | Uniprot | |
| S337 | Phosphorylation | Uniprot | |
| S338 | Phosphorylation | Uniprot | |
| Y341 | Phosphorylation | Uniprot | |
| Y347 | Phosphorylation | Uniprot | |
| K350 | Acetylation | Uniprot | |
| K350 | Methylation | Uniprot | |
| K350 | Sumoylation | Uniprot | |
| K350 | Ubiquitination | Uniprot | |
| R352 | Methylation | Uniprot | |
| Y357 | Phosphorylation | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| S361 | Phosphorylation | Uniprot | |
| S362 | Phosphorylation | Q9BUB5 (MKNK1) | Uniprot |
| S363 | Phosphorylation | Q9BUB5 (MKNK1) | Uniprot |
| S364 | Phosphorylation | Q9BUB5 (MKNK1) | Uniprot |
| S365 | Phosphorylation | Uniprot | |
| Y366 | Phosphorylation | Uniprot | |
| S368 | Phosphorylation | Uniprot | |
| R370 | Methylation | Uniprot | |
| R371 | Methylation | Uniprot |
研究背景
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1.
(Microbial infection) May play a role in HCV RNA replication.
(Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis.
Arg-194, Arg-206 and Arg-225 are dimethylated, probably to asymmetric dimethylarginine.
Sumoylated.
Nucleus. Cytoplasm.
Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes (PubMed:17289661).
Cytoplasm.
Note: (Microbial infection) In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication dependent manner.
Identified in the spliceosome C complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SEPT6. Interacts with C9orf72. Interacts with KHDRBS1. Interacts with UBQLN2.
(Microbial infection) Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA.
研究领域
· Genetic Information Processing > Transcription > Spliceosome.
限制条款
产品的规格、报价、验证数据请以官网为准，官网链接：www.affbiotech.com | www.affbiotech.cn（简体中文）| www.affbiotech.jp（日本語）产品的数据信息为Affinity所有，未经授权不得收集Affinity官网数据或资料用于商业用途，对抄袭产品数据的行为我们将保留诉诸法律的权利。
产品相关数据会因产品批次、产品检测情况随时调整，如您已订购该产品，请以订购时随货说明书为准，否则请以官网内容为准，官网内容有改动时恕不另行通知。
Affinity保证所销售产品均经过严格质量检测。如您购买的商品在规定时间内出现问题需要售后时，请您在Affinity官方渠道提交售后申请。产品仅供科学研究使用。不用于诊断和治疗。
产品未经授权不得转售。
Affinity Biosciences将不会对在使用我们的产品时可能发生的专利侵权或其他侵权行为负责。Affinity Biosciences, Affinity Biosciences标志和所有其他商标所有权归Affinity Biosciences LTD.