产品: PTHR1 小鼠 单克隆 抗体
货号: BF8066
描述: Mouse monoclonal antibody to PTHR1
应用: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 70KD; 66kD(Calculated).
蛋白号: Q03431

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产品描述

来源:
Mouse
应用:
WB 1:1000-1:10000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Monoclonal [AFfirm8066]
特异性:
PTHR1 Antibody detects endogenous levels of total PTHR1.
偶联:
Unconjugated.
纯化:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

MGC138426; MGC138452; Parathyroid hormone 1 receptor; Parathyroid hormone/parathyroid hormone related peptide receptor; Parathyroid hormone/parathyroid hormone related protein receptor; Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH receptor; PTH/PTHr receptor; PTH/PTHrP receptor; PTH/PTHrP type I receptor; PTH1 receptor; PTH1R; PTH1R_HUMAN; PTHR 1; PTHR; PTHR1;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
Q03431 PTH1R_HUMAN:

Expressed in most tissues. Most abundant in kidney, bone and liver.

序列:
MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM

翻译修饰 - Q03431 作为底物

Site PTM Type Enzyme
Y23 Phosphorylation
S73 Phosphorylation
S91 Phosphorylation
T99 Phosphorylation
S101 Phosphorylation
T192 Phosphorylation
Y320 Phosphorylation
T387 Phosphorylation
K388 Ubiquitination
T392 Phosphorylation
S473 Phosphorylation
K484 Ubiquitination
S489 Phosphorylation
S491 Phosphorylation
S492 Phosphorylation
S493 Phosphorylation
Y494 Phosphorylation
S495 Phosphorylation
Y496 Phosphorylation
S501 Phosphorylation
T503 Phosphorylation
S504 Phosphorylation
S519 Phosphorylation
T547 Phosphorylation
T551 Phosphorylation
T591 Phosphorylation

研究背景

功能:

Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

翻译修饰:

N-glycosylated.

细胞定位:

Cell membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed in most tissues. Most abundant in kidney, bone and liver.

亚基结构:

Interacts (via N-terminal extracellular domain) with PTHLH and PTH. Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer.

蛋白家族:

Belongs to the G-protein coupled receptor 2 family.

研究领域

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

· Organismal Systems > Excretory system > Endocrine and other factor-regulated calcium reabsorption.

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